The association of smoking and alcohol use with age-related macular degeneration in the oldest old: the Study of Osteoporotic Fractures.

Purpose: To estimate the incidence of age-related macular degeneration (AMD) and the association of smoking and alcohol in a population of older women.

Design: Prospective cohort study.

Methods: Subjects were women who attended the Study of Osteoporotic Fractures year-10 and year-15 follow-up clinic visits and had fundus photographs taken at both visits (n = 1958; 245 Black and 1713 White subjects; mean age at year 10 visit, 78.

Long-term safety and efficacy of repositioning dislocated plate haptic intraocular lenses in the ciliary sulcus.

Purpose: To report safety and efficacy outcomes of repositioning posterior dislocated plate haptic lenses (PHLs) in the ciliary sulcus (CS).

Design: Retrospective interventional case series.

Methods: Fifteen consecutive eyes with dislocated PHL repositioned in the CS were reviewed retrospectively.

Safety results of two phase III trials of an intravitreous injection of highly purified ovine hyaluronidase (Vitrase) for the management of vitreous hemorrhage.

Purpose: To evaluate the safety of intravitreous ovine hyaluronidase for the management of vitreous hemorrhage.

Design: Two prospective, randomized, placebo-controlled, double-masked studies. Pooled efficacy data are presented in a companion article in this issue of The Journal.

Pooled efficacy results from two multinational randomized controlled clinical trials of a single intravitreous injection of highly purified ovine hyaluronidase (Vitrase) for the management of vitreous hemorrhage.

Purpose: To evaluate the efficacy of intravitreous ovine hyaluronidase for the management of vitreous hemorrhage.

Design: Two prospective, randomized, placebo-controlled, double-masked studies. Safety data are presented in a companion article in The Journal.

Efficacy of verteporfin photodynamic therapy on laser-induced choroidal neovascularization and the ancillary effect on diabetic microvasculopathy.

Purpose: To demonstrate the efficacy of photodynamic therapy (PDT) in treating choroidal neovascularization (CNV) induced by laser photocoagulation for diabetic macular edema and its ancillary effect on surrounding diabetic microvascular abnormalities.

Methods: A retrospective interventional case series study in a clinical practice setting of four patients with proliferative diabetic retinopathy and clinically significant macular edema who had developed classic CNV in proximity to the area of previous laser photocoagulation. The lesions were treated with verteporfin PDT and followed with serial fluorescein angiography.

Chronic central serous chorioretinopathy: photodynamic therapy.

Purpose: To demonstrate, using optical coherence and fluorescien angiography, the efficacy of photodynamic therapy in treating chronic central serous chorioretinopathy.

Design: Interventional case series.

Methods: A retrospective study in a clinical practice setting of four patients (five eyes) with chronic central serous chorioretinopathy.