Publications by authors named "Edgar Ianhez Junior"
Article Synopsis
- Gabapentin is eliminated from the body unchanged through urine, with specific transporters (OCT2 and OCTN1) influencing its excretion.
- This study examined how genetic variations (polymorphisms) affect gabapentin's pharmacokinetics in 53 patients with chronic pain, identifying two specific genetic markers but finding only limited impact on drug metabolism.
- While renal function and absorption play a major role in gabapentin's clinical pharmacokinetics, the genetic variant SLC22A4 c.1507C>T does not significantly influence its absorption or elimination.