Genome sequence of bacteriophage Omen.

We report the genome of phage Omen, isolated from a Portuguese orchard. Omen has a genome size of 85,304 bp, belongs to the genus (myovirus morphotype), and shares over 80% nucleotide identity with various phage genomes.

Lung abscess due to associated with SARS CoV-2 infection in pregnancy: Unusual presentation and complication of a commensal bacteria during pregnancy.

is a commensal bacterium reported in a few cases as the causative agent of brain and lung abscesses, pneumonia, and endocarditis. Lung abscesses due to are rare, especially in pregnancy. We describe the first case of lung abscess due to in a pregnant woman.

Flatness and intrinsic curvature of linked-ring membranes.

Recent experiments have elucidated the physical properties of kinetoplasts, which are chain-mail-like structures found in the mitochondria of trypanosome parasites formed from catenated DNA rings. Inspired by these studies, we use Monte Carlo simulations to examine the behavior of two-dimensional networks ("membranes") of linked rings. For simplicity, we consider only identical rings that are circular and rigid and that form networks with a regular linking structure.

Safety and Efficacy Considerations of Gabapentin as Adjunctive Therapy to Opioids in the Perioperative Setting for Older Adults.

While opioids have historically been the initial choice of analgesic for both acute and chronic pain, legislative and deprescribing trends as a result of the opioid epidemic have demonstrated an increase in the use of adjunctive therapies. These adjunctive agents are being utilized with increased frequency, especially in older adult patients, as a mechanism to mitigate any likelihood of dependency and in an effort to provide multimodal pain management. As this patient population can be more challenging because of comorbidities, the presence of polypharmacy, pharmacokinetic, and pharmacodynamic changes, it is important to evaluate the risk of any relevant adverse effects for opioids and adjuncts that can lead to higher risk of opioid toxicities.

[Occupational exposure to influenza virus of the wild birds].

Wild waterfowl are considered the main natural reservoir of influenza viruses and they have contributed to the reassortment of both pandemic viruses and viruses responsible for outbreaks of avian influenza in wild and domestic species. In order to determinate the factors involved, we reviewed the human cases of avian influenza related to the management of wild birds, the use of personal protective equipment, as well as the basis of surveillance programs of highly pathogenic avian influenza in wild birds in Spain. The direct transmission of influenza virus from wild birds to humans is a rare event.

Streptomycin hydrazone derivatives: synthesis and molecular recognition in aqueous solution.

Five hydrazone derivatives of streptomycin were synthetized (D0h, D1ph, D2bt, D3dctf, D4ag) and characterized by IR, 1H and 13C NMR spectroscopy, mass spectrometry and elemental analysis. Protonation constants were determined by potentiometry for all derivatives. D1ph and D2bt derivatives were investigated as receptors of dicarboxylates and adenine nucleotides in aqueous solution by potentiometric and 1H NMR titrations.

Minor myocardial damage is a prevalent condition in patients with acute heart failure syndromes and preserved systolic function with long-term prognostic implications: a report from the CIAST-HF (Collaborative Italo-Argentinean Study on cardiac Troponin T in Heart Failure) study.

Background: Half of patients with acute heart failure syndromes (AHFS) have preserved left ventricular ejection fraction (PLVEF). In this setting, the role of minor myocardial damage (MMD), as identified by cardiac troponin T (cTnT), remains to be established.

Aim: To evaluate the prevalence and long-term prognostic significance of cTnT elevations in patients with AHFS and PLVEF.

Stress concentration and size effect in fracture of notched heterogeneous material.

We study theoretically and experimentally the effect of long-range correlations in the material microstructure on the stress concentration in the vicinity of the notch tip. We find that while in a fractal continuum the notch-tip displacements obey the classic asymptotic for a linear elastic continuum, the power-law decay of notch-tip stresses is controlled by the long-range density correlations. The corresponding notch-size effect on fracture strength is in good agreement with the experimental tests performed on notched sheets of different kinds of paper.

Increased levels of cardiac troponin-T in outpatients with heart failure and preserved systolic function are related to adverse clinical findings and outcome.

Background: The implications of increased levels of cardiac troponin T in congestive heart failure with preserved systolic function have been poorly evaluated. We hypothesized that its presence might be related to disease severity and prognosis in this setting.

Methods: Clinical, echocardiographic, 6-min walking test and laboratory data were prospectively obtained in 69 congestive heart failure outpatients with ejection fraction > or = 40%.

Reduced systolic performance by tissue Doppler in patients with preserved and abnormal ejection fraction: new insights in chronic heart failure.

Background: Tissue Doppler imaging (TDI) is useful in the evaluation of systolic and diastolic function. It allows assessment of ventricular dynamics in its longitudinal axis. We sought to investigate the difference in systolic and diastolic longitudinal function in patients with chronic heart failure (CHF) with normal and reduced ejection fraction.

Ongoing myocardial injury in stable severe heart failure: value of cardiac troponin T monitoring for high-risk patient identification.

Background: The progression of chronic heart failure (CHF) is related to ongoing myocyte loss, which can be detected by cardiac troponin T (cTnT). We examined the prevalence and prognostic value of increased cTnT concentrations in serial blood specimens from patients with severe CHF.

Methods And Results: Clinical, echocardiographic, and 6-minute walk test data were collected prospectively at baseline and at 1 year in 115 outpatients (mean age, 61+/-11 years; 75% men; 62% coronary heart disease) with CHF and a left ventricular ejection fraction <40%.