Publications by authors named "Edgar Brodkin"
Article Synopsis
- The study evaluated the accuracy of Agile scores (Agile 3+ and Agile 4) for diagnosing advanced liver fibrosis and cirrhosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), and chronic hepatitis B or C (CHB/C).
- It included 4,243 patients and found that Agile scores had diagnostic accuracy comparable to liver stiffness measurements (LSM) in MASLD and ALD, but performed less effectively in CHB/C.
- The results suggest that using Agile scores alongside existing biomarkers like FIB-4 can improve diagnosis by reducing indeterminate results and enhancing specificity for advanced liver conditions.
Article Synopsis
- A multicenter study involving 5,648 patients aimed to validate the liver stiffness thresholds proposed by the Baveno VI consensus for diagnosing compensated advanced chronic liver disease (cACLD).
- The results showed that the original cut-offs of <10 kPa and >15 kPa had 75% sensitivity and 96% specificity, but a modified dual cut-off of <7 kPa and >12 kPa provided better diagnostic accuracy with 91% sensitivity and 92% specificity.
- The study recommends using the new thresholds for better diagnosis, especially with lower cut-offs (like <8 kPa) for patients with non-alcoholic fatty liver disease and alcohol-related liver disease.
Background: Impaired thrombin generation (TG) in patients with acquired coagulopathy, is due to low coagulation factors and thrombocytopenia. The latter is typically treated with platelet transfusions and the former with plasma and occasionally with prothrombin complex concentrates (PCCs). We hypothesized that manipulating the concentrations of coagulation factors might result in restoration of platelet-dependent TG over and above that of simple replacement therapy.
View Article and Find Full Text PDFBackground & Aims: The Baveno VI guidelines propose that cirrhotic patients with a liver stiffness measurement (LSM) <20kPa and a platelet count >150,000/μl can avoid screening endoscopy as their combination is highly specific for excluding clinically significant varices. The aim of the study was to validate these criteria.
Methods: Transient elastography data was collected from two institutions from 2006-2015.