Publications by authors named "Eder da Silva Dolens"
Article Synopsis
- This study investigated how the probiotic Bifidobacterium animalis subsp. lactis HN019 affects the severity of experimental periodontitis (EP) in rats undergoing chemotherapy with 5-fluorouracil (5FU).
- Eighty male rats were assigned to different treatment groups, including those receiving only 5FU, only the probiotic, both together, or other combinations, and were analyzed at the end of the treatment period.
- Results indicated that the combination of 5FU and the probiotic reduced bone loss and improved immune response in periodontal tissues compared to 5FU alone, suggesting that B. lactis HN019 could help manage periodontitis during chemotherapy.
Exploring the combination of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis.
J Oral Pathol Med
May 2023
Background: While the relevance of the World Health Organization histopathological grading system as a prognostic tool for oral squamous cell carcinoma has received many critics, other histopathological features such as tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding are displaying promising results. Here, we evaluated the prognostic impact of the incorporation of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding into World Health Organization histopathological grading for patients with oral squamous cell carcinoma.
Methods: A total of 95 patients with early-stage oral squamous cell carcinoma were enrolled in the study, and World Health Organization tumor grading, tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding were evaluated in surgical slides stained with hematoxylin and eosin.
Article Synopsis
- This systematic review aims to identify the key histopathological features that influence treatment planning and risk assessment in oral squamous cell carcinoma (OSCC) due to inconsistencies in existing studies.
- Researchers analyzed 172 articles from 1999 to 2021, confirming the prognostic significance of features like depth of invasion (DOI) and extranodal extension (ENE), along with others like perineural and lymphovascular invasion.
- The findings highlight additional features, such as tumor budding and tumor-stroma ratio, that may impact survival predictions, but most studies were found to have low or moderate quality, suggesting areas for improvement in future research.
Oropharyngeal cancer is the 11th most common cancer worldwide. The diagnostic method of choice for oral cavity lesions is biopsy and pathological examination. Cytopathology is a simple and inexpensive method, but it is not yet widespread among dental professionals.
View Article and Find Full Text PDF