Intranasal esketamine as therapeutic option: a case report of an adolescent with treatment resistant depression.

Depression is among the most common mental health disorders worldwide and treatment resistant depression (TRD) represents a major challenge for both patients and clinicians. In recent years ketamine has received attention as an antidepressant agent, demonstrating promising results in TRD in adults. To date, few attempts have been made in treating adolescent TRD with ketamine and none have used intranasal application.

X-Ray Protective Aprons Re-Evaluated.

Background: The evaluation of the protective effect of X-ray protective clothing requires new criteria. The current concept assumes more or less uniform covering of the torso with protective material. The frequently worn heavy wrap-around aprons can weigh 7 to 8 kg.

Conspiracy beliefs and COVID-19 guideline adherence in adolescent psychiatric outpatients: the predictive role of adverse childhood experiences.

Background: Conspiracy beliefs have become widespread throughout the COVID-19 pandemic. Previous studies have shown that endorsing conspiracy beliefs leads to lower protective guideline adherence (i.e.

Use of effective dose to assess x-ray protective clothing.

This review article provides an overview on the results of studies conducted by the authors to improve the current personal protection concept in the clinical application of x-rays. With the aid of personal dose equivalent measurements during radiologically guided clinical interventions, laboratory tests using the Alderson-Rando phantom as well as Monte Carlo simulations various x-ray application scenarios were investigated. The organ doses and the effective doses of staff persons standing near the patient were determined.

Nasal glial heterotopia: A rare interdisciplinary surgical challenge in newborns.

Nasal Glioma (NG) represents a rare congenital abnormality of the neonate, which can be associated with skull defects or even a direct communication to the central nervous system. MRI serves valuable information for differentiation from encephalocele, dermoid cyst and congenital hemangioma. Complete resection remains the treatment of choice.

Shielding effectiveness of X-ray protective garment.

Purpose: Certification of the X-ray shielding garment is based on attenuation testing on flat material samples. We investigated the difference of shielding effectiveness compared to realistic use when the garment is worn on the body of a staff person.

Methods: Attenuation factors of X-ray protective aprons have been evaluated for several clinical scenarios with Monte Carlo (MC) calculations based on the ICRP female reference model and an experimental setup.

The (mis)perception of sleep: factors influencing the discrepancy between self-reported and objective sleep parameters.

Study Objectives: Self-reported perception of sleep often differs from objective sleep study measures, but factors predicting the discrepancy between self-reported and objective sleep parameters are controversial, and a comparison of laboratory vs ambulatory polysomnography (PSG) is lacking.

Methods: We retrospectively analyzed PSGs conducted between 2012 and 2016. Linear regression was applied to predict the discrepancy between self-reported and objective sleep parameters (total sleep time, sleep efficiency, sleep latency, using age, sex, arousal index, type of sleep disorder, and PSG type [laboratory vs ambulatory] as regressors).

TERTIARY X-RADIATION-A PROBLEM FOR STAFF PROTECTION?

The influence of tertiary x-radiation on the radiological staff is widely unknown. Tertiary radiation is caused as the scattered radiation of the patient impacts the walls, floor, ceiling and surrounding air. The question that arises is does tertiary x-radiation provide a relevant contribution to the staff doses.

IEC 61331-1: A new setup for testing lead free X-ray protective clothing.

Purpose: Lead free protective clothing can create a higher part of secondary radiation (SR) than products that are based on lead. Hence, the attenuation properties may be downgraded. The international measuring standard IEC 61331-1:2014 declares the "inverse broad beam geometry" (IBG) as standard method, which has recently been modified to IBG by the Physikalisch Technische Bundesanstalt (PTB).

Survey to identify depth of penetration of critical incident reporting systems in Austrian healthcare facilities.

Incident reporting systems or so-called critical incident reporting systems (CIRS) were first recommended for use in health care more than 15 years ago. The uses of these CIRS are highly variable among countries, ranging from being used to report critical incidents, falls, or sentinel events resulting in death. In Austria, CIRS have only been introduced to the health care sector relatively recently.

Assessment of clinical occupational dose reduction effect of a new interventional cardiology shield for radial access combined with a scatter reducing drape.

Objectives: To assess the occupational dose reduction effect of a new interventional cardiology shield for radial access combined with a scatter reducing drape.

Background: Transradial access for catheterization has been shown to increase occupational radiation dose. Current shielding techniques are primarily based on the femoral access.

A New Design of a Lead-Acrylic Shield for Staff Dose Reduction in Radial and Femoral Access Coronary Catheterization.

Purpose: Today's standard radiation protection during coronary angiography and percutaneous coronary interventions is the combined use of lead acrylic shields and table-mounted lower body protection. Ambient dose measurements, however, have shown that these protection devices need improvement.

Materials And Methods: Using an anthropomorphic physical phantom, various scenarios were investigated with respect to personnel exposure: a) enlarging the shield b) adding a flexible protective curtain to the bottom side of the shield, and c) application of radioprotective patient drapes.

Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways.

Background: Glioblastoma multiforme (GBM) is a highly aggressive tumor of the central nervous system with a dismal prognosis for affected patients. Aberrant protein kinase C (PKC) signaling has been implicated in gliomagenesis, and a member of the PKC-activated protein kinase D (PRKD) family, PRKD2, was identified as mediator of GBM growth in vitro and in vivo.

Methods: The outcome of PRKD2 silencing and pharmacological inhibition on glioma cell proliferation was established with different glioma cell lines.

Clinical study results from a randomized controlled trial of cognitive behavioural guided self-help in patients with partially remitted depressive disorder.

Objectives: Cognitive behavioural guided self-help has been shown to be effective in mild and moderate depressive disorder. It is not known, however, if it is effective in individuals with partially remitted depressive disorder, which is a serious clinical problem in up to 50-60% of treated patients. This study is the first one to examine the clinical benefit of this intervention in this patient population.

On the role of 25-hydroxycholesterol synthesis by glioblastoma cell lines. Implications for chemotactic monocyte recruitment.

Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor and is invariably fatal to affected patients. Oxysterols belong to a class of bioactive lipids that are implicated in neurological disease and are associated with various types of cancer. Here, we investigated expression and transcriptional regulation of cholesterol 25-hydroxylase (CH25H) in human U87MG and GM133 glioblastoma cell lines.

Emission of fluorescent x-radiation from non-lead based shielding materials of protective clothing: a radiobiological problem?

The aim of this study was to investigate the effectiveness of different shielding materials in protective clothing using dicentric frequency in human peripheral lymphocytes as a marker of radiation-induced damage. Blood samples from a healthy donor were exposed to 70 kV x-rays behind shielding materials lead (Pb), tin/antimony (Sn + Sb) and bismuth barrier/tin/tungsten (Bi + Sn + W) with the same nominal lead equivalent value of 0.35 mm lead.

Ictal fear auras after selective amygdalohippocampectomy: the use of ictal SPECT and scalp EEG in the presurgical reevaluation.

The perception of fear aura in complex partial seizures is linked to epileptic discharges within mesial temporal lobe structures. Although selective amygdalohippocampectomy often leads to favorable seizure control, persistence of fear auras after surgery can hamper quality of life significantly. We describe two patients with persistent fear auras after selective amygdalohippocampectomy who had to be reevaluated for a second operative procedure.

Migraine in patients with eating disorders: a study using a sister-pair comparison design.

Objective: To evaluate the relationship between migraine and eating disorders by applying a special study design.

Background: To date, only a few studies have assessed eating disorders and eating behavior in patients with migraine.

Methods: The distinctive feature of this design is the comparison of sister pairs with one sister suffering from an eating disorder according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition and the other being free of such disease.

Air-permeable hole-pattern and nose-droop control improve aerodynamic performance of primary feathers.

Primary feathers of soaring land birds have evolved into highly specialized flight feathers characterized by morphological improvements affecting aerodynamic performance. The foremost feathers in the cascade have to bear high lift-loading with a strong bending during soaring flight. A challenge to the study of feather aerodynamics is to understand how the observed low drag and high lift values in the Reynolds (Re) regime from 1.

X-Ray protective clothing: does DIN 6857-1 allow an objective comparison between lead-free and lead-composite materials?

Purpose: The validity of DIN 6857-1 to establish lead equivalence for protective clothing is evaluated by Monte Carlo simulations and measurements.

Materials And Methods: Commercially available protective clothing made of lead, lead-free and lead-composite materials has been tested regarding its protective efficacy. The analysis has been performed on the one hand in accordance with the test conditions described in the manufacturing standard DIN EN 61331-3 and on the other hand following the new DIN 6857-1 standard.

Recurrent Pott's puffy tumor - atypical presentation of a rare disorder.

We report the case of a 14-year-old girl who presented with an 8-week history of unilateral pansinusitis. In the course of the disease a right-side frontal swelling was observed, which disappeared following antibiotic treatment. Four weeks later, however, the swelling reappeared and was now diagnosed as recurrent Pott's puffy tumor.

Medulloblastoma in a child with down syndrome: long-term remission with multimodality treatment.

A 4(3/4)-year-old male with Down syndrome (DS) presented with unsteady gait and fatigue. Neuroimaging revealed a cerebellar mass with concomitant obstructive hydrocephalus and additional metastatic lesions. He was successfully treated and is still in complete remission 5 years from diagnosis.