Role of the PRC2-Six1-miR-25 signaling axis in heart failure.

The reduced expression of cardiac sarco-endoplasmic reticulum Ca ATPase (SERCA2a) is a hallmark of heart failure. We previously showed that miR-25 is a crucial transcriptional regulator of SERCA2a in the heart. However, the precise mechanism of cardiac miR-25 regulation is largely unknown.

Intra-surface plasmon coupling between smooth and nanoporous blocks in a gold nanorod.

We report an intraparticle surface plasmon coupling in Au nanorod structures consisting of half smooth and half nanoporous surface morphology; the relative ratio and the diameter difference between each block were important in determining the overall optical properties of such nanostructures.