The Potential of Vouacapanes from Vogel Against COVID-19 Cytokine Storm.

The emergence of the COVID-19 pandemic has led to the search for potential therapeutic responses for various aspects of this disease. Fruits of Vogel (Fabaceae), sucupira, have been used in Brazilian traditional medicine because of their anti-inflammatory properties, which have been proven , and . Therefore, the aim of this work is to evaluate oleoresin and isolated diterpenes by anti-inflammatory models.

Effects of liquid extract from Plinia cauliflora fruits residues on Chinese hamsters biochemical parameters.

Plinia cauliflora (Mart.) Kausel, popularly known as jabuticaba, is rich in polyphenols. Phenolic compounds exhibit several biological properties, which reflect on biomarkers such as biochemical parameters.

Treatment of cosmetic industry wastewater by flotation with Moringa oleifera Lam. and aluminum sulfate and toxicity assessment of the treated wastewater.

The production of personal hygiene and body products generates wastewater with a high load of surfactants, a high chemical oxygen demand (COD), and abundant oils and greases. Aluminum sulfate (AS) and two solutions of natural coagulant from Moringa oleifera Lam. seeds prepared with a 1M NaCl solution and 1.

Enhanced Skin Permeation of Punicalagin after Topical Application of Pluronic Micelles or Vesicles Loaded with Lafoensia pacari Extract.

Punicalagin, the principal ellagitannin of leaves, has proven antioxidant activity, and standardized extracts of can be topically used for skin aging management. We hypothesized that Pluronic nanomicelles or vesicles could solubilize sufficiently large amounts of the standardized extracts of and provide chemical stability to punicalagin. The standardized extracts of were obtained with an optimized extraction procedure, and the antioxidant activity was characterized.

Crude plant extract versus single compounds for vitiligo treatment: Ex vivo intestinal permeability assessment on Brosimum gaudichaudii Trécul.

Roots´ bark extract of Brosimum gaudichaudii Trécul (EBGT) is traditionally used for photochemotherapy of vitiligo due to the presence of furanocoumarins psoralen (PSO) and 5-methoxypsoralen (5-MOP) as major compounds. Though plant extracts may provide additional highly permeable psoralens-like substances which may act synergically on vitiligo's therapy. Thus, the aim of this work was to develop an LC-MS/MS method for screening new highly permeable furanocoumarins from B.

Acute exposure to environmentally relevant concentrations of benzophenone-3 induced genotoxicity in Poecilia reticulata.

The organic UV filter benzophenone-3 (BP-3), widely used in the commercial formulations of sunscreens and personal care products, is considered an emerging pollutant and has been associated with several human and environmental health concerns. However, knowledge about their mode of action and ecotoxicity on aquatic biota is scarce. In this scenario, the objective of this work was to evaluate the genotoxic, mutagenic, and erythrotoxicity effects of BP-3 in the guppy Poecilia reticulata after acute exposure.

Curcuma supplementation in high-fat-fed C57BL/6 mice: no beneficial effect on lipid and glucose profile or prevention of weight gain.

Purpose: This experimental study investigated the effects of curcuma supplementation on weight gain, Body Adiposity Index, glucose and lipid profile, and liver and pancreas histology in C57BL/6 mice fed with a high-fat diet.

Methods: 40 animals were separated into four groups: standard diet (SD), standard diet plus curcuma (SD + C), high-fat diet (HFD), and high-fat diet plus curcuma (HFD + C). Curcuma dose was 8 mg/animal/day.

Radical Scavenger Capacity of Jabuticaba Fruit () and Its Biological Effects in Hypertensive Rats.

Jabuticaba is an exotic fruit native to Brazil that has been arousing medicinal interest. Using chemical (HPLC-PDA, resonance mass spectra, and NMR), electroanalytical (differential pulse voltammetry, radical scavenging assay), and pharmacological ( and ) approaches, we have identified its bioactive compounds and hypotensive effects on hypertensive rats. The hydroalcoholic extract of jabuticaba (HEJ) presents a great quantity of phenolic compounds, and several molecules with hydroxyl groups present high efficiency as an antioxidant.

Anti-inflammatory activity of nanoemulsions of essential oil from Rosmarinus officinalis L.: in vitro and in zebrafish studies.

The essential oil from Rosmarinus officinalis L. (OERO) has bioactive compounds with anti-inflammatory activity. The objective of this study was to evaluate the anti-inflammatory potency of nanoemulsions containing essential oil of Rosmarinus officinalis L.

Development and Validation of a HPLC-UV Method for the Evaluation of Ellagic Acid in Liquid Extracts of L. (Myrtaceae) Leaves and Its Ultrasound-Assisted Extraction Optimization.

A simple HPLC-UV method has been developed and validated for the quantification of ellagic acid (EA) in ethanol extracts of L. (Myrtaceae) leaves. The ultrasound-assisted extraction (UAE) optimization was performed using a Box Behnken design (3) combined with response surface methodology to study the effects of the ethanol concentration (%, w/w), extraction time (minutes), and temperature (°C) on the EA concentration.

Obtaining a Dry Extract from the Leaves with Potential for Antiulcer Activity.

Background: leaves are commonly used in Brazil as a medicinal plant.

Objective: To obtain hydroalcoholic dried extract by nebulization and evaluate its antiulcerogenic potential.

Materials And Methods: Plant material and hydroalcoholic extract were processed and analyzed for their physicochemical characteristics.

Essential Oil Composition, Antimicrobial and Pharmacological Activities of Cham. (Verbenaceae) From São Gonçalo do Abaeté, Minas Gerais, Brazil.

Background: (Verbenaceae) is used in Brazilian folk medicine as an antiseptic, and it is usually applied topically on skin, mucous membranes, mouth, and throat, or used for vaginal washings.

Objectives: To analyze the chemical composition of the essential oil from collected in São Gonçalo do Abaeté, Minas Gerais and grown in Hidrolândia, Goiás; to evaluate the antimicrobial activity of the essential oil, crude ethanol extract, and hexane, dichloromethane, ethyl-acetate, and aqueous fractions (AFs); to study the antinociceptive, anti-inflammatory, and central nervous system activities of the crude ethanol extract.

Materials And Methods: The essential oils were obtained by hydro-distillation using a Clevenger-type apparatus and analyzed by GC/MS.

Jabuticaba-Induced Endothelium-Independent Vasodilating Effect on Isolated Arteries.

Background:: Despite the important biological effects of jabuticaba, its actions on the cardiovascular system have not been clarified.

Objectives:: To determine the effects of jabuticaba hydroalcoholic extract (JHE) on vascular smooth muscle (VSM) of isolated arteries.

Methods:: Endothelium-denuded aortic rings of rats were mounted in isolated organ bath to record isometric tension.

Optimization of Ultrasound-assisted Extraction of Phenolic Compounds from Myrcia amazonica DC. (Myrtaceae) Leaves.

Background: Myrcia amazonica. DC is a species predominantly found in northern Brazil, and belongs to the Myrtaceae family, which possess various species used in folk medicine to treat gastrointestinal disorders, infectious diseases, and hemorrhagic conditions and are known for their essential oil contents.

Materials And Methods: This study aimed applied the Box-Behnken design combined with response surface methodology to optimize ultrasound-assisted extraction of total polyphenols, total tannins (TT), and total flavonoids (TF) from M.

Ultrasound-assisted extraction of azadirachtin from dried entire fruits of Azadirachta indica A. Juss. (Meliaceae) and its determination by a validated HPLC-PDA method.

Azadirachta indica A. Juss., also known as neem, is a Meliaceae family tree from India.

Bioactive Compounds Found in Brazilian Cerrado Fruits.

Functional foods include any natural product that presents health-promoting effects, thereby reducing the risk of chronic diseases. Cerrado fruits are considered a source of bioactive substances, mainly phenolic compounds, making them important functional foods. Despite this, the losses of natural vegetation in the Cerrado are progressive.

Vasorelaxant and Hypotensive Effects of Jaboticaba Fruit (Myrciaria cauliflora) Extract in Rats.

This study's aim was to determine the effect of hydroalcoholic extract of M. cauliflora (HEMC) on vascular tension and blood pressure in rats. In our in vitro studies using precontracted isolated aortas from rats, HEMC and acetylcholine (positive control) induced relaxation only in vessels with endothelium.

Evaluation of extraction method on the chemical composition in Apeiba tibourbou Aubl's extracts.

Background: The extraction method of bioactive compounds is an important step in the manufacturing of herbal medicines, because secondary metabolites with therapeutic potential are usually found in small quantities in plant materials.

Objective: Due the potential of Apeiba tibourbou Aubl, this study aimed to evaluate the impact of the extraction method on the quality of herbal extract and optimize the extraction of fatty acid, rosmarinic (Ra) and caffeic (Ca) acid from A. tibourbou.

Technical aspects on production of fluid extract from Brosimum gaudichaudii Trécul roots.

Instruction: Despite the increased use of Brosimum gaudichaudii roots as raw material on medicine to treatment of vitiligo, there are not studies that showing the impact of unit operations on the quality and standardized of the extract of B. gaudichaudii. The quality of the herbal extract is essential to ensure the safety and efficacy of pharmaceutical product.

Obtainment of pellets using the standardized liquid extract of Brosimum gaudichaudii Trécul (Moraceae).

Background: The standardized liquid extract of Brosimum gaudichaudii Trécul is an alternative for the treatment of vitiligo. There is a shortage of solid oral dosage forms developed from standardized extracts of this plant specie.

Objective: This study is aimed to obtain pellets with a standardized liquid extract of B.

The effects of extraction method on recovery rutin from Calendula officinalis L. (Asteraceae).

Background: Calendula officinalis L. (Asteraceae) is a Mediterranean specie, but in Europe and America it is cultivated for ornamental or medicinal purposes. This species is widely used for presenting activities, antiinflammatory antibacterial and antioxidant.

Chemical Constituents of Essential Oil from Lippia sidoides Cham. (Verbenaceae) Leaves Cultivated in Hidrolândia, Goiás, Brazil.

Several studies involving the family Verbenaceae, occurring in the Brazilian Cerrado, have emphasized the popular use of many aromatic species. We highlight the use of Lippia sidoides Cham., known as "alecrim pimenta," native to northeastern Brazil and northern Minas Gerais.

Psoralen and bergapten: in silico metabolism and toxicophoric analysis of drugs used to treat vitiligo.

Purpose: To discuss the contribution of psoralen and bergapten metabolites on psoralens toxicity.

Methods: Computational chemistry prediction of metabolic reactions and toxicophoric groups based on the expert systems Derek and Meteor.

Results: a total of 15 metabolites were suggested for both psoralen and bergapten based on phase 1 and 2 biotransformations until the 3rd generation.