Publications by authors named "Edel Pineda"
Early life stress (ELS) programs hypothalamus-pituitary-adrenal (HPA) axis activity and affects synaptic plasticity and cognitive performance in adults; however, the effects of ELS during the temporal window of vulnerability are poorly understood. This study aimed to thoroughly characterize the effects of ELS in the form of periodic maternal separation (MS180) during the time of exposure to stress. Hippocampal corticotropin-releasing hormone (CRH) gene expression and baseline HPA axis activity were analyzed at postnatal (P) days 6, 12, 15, and 21, and in adulthood (P75); these factors were correlated with plasticity markers and adult behavior.
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- Early life stress (ELS) significantly worsens depressive-like behavior and causes metabolic imbalances in middle-aged rats compared to younger ones, highlighting age-dependency of these effects.
- Maternal separation (MS180) led to more pronounced depressive symptoms and obesity in middle-aged rats, while younger rats displayed similar behavioral effects but less severe overall.
- ELS negatively impacted hippocampal neurogenesis differently based on age, with younger rats showing dorsal neurogenesis reduction, while middle-aged rats experienced declines in both dorsal and ventral neurogenesis, indicating early-age-related changes in mental and metabolic health linked to stress.