Determining female-specific high-intensity activity GPS thresholds in women's rugby union: Use of current use of male-derived absolute speed thresholds underestimates true levels.

GPS speed thresholds in women's rugby union are usually based on data derived from the men's game. However, evidence suggests the maximum speeds achieved by female players are 2-8 km.h slower and the volume of high-intensity running (HIR) in women's rugby may be underestimated.

Trunk Kinematics of Experienced Riders and Novice Riders During Rising Trot on a Riding Simulator.

Asymmetry of horses and humans is widely acknowledged, but the influence of one upon the other during horse riding is poorly understood. Riding simulators are popular for education of beginners and analysis of rider biomechanics. This study compares trunk kinematics and saddle forces of 10 experienced riders (ER) and 10 novice riders (NR) performing rising trot on a simulator.

Putting the Boom, Boom, Boom into Physical Activity and Health: Music Festivals as a Positive Health Alternative to Couch Fandom.

: Despite the popularity of outdoor music festivals in the UK, no evidence exists of the volume or intensity of movement that occurs through attendance at these festivals and the potential health benefits this may provide. The aim of this study was to accurately record the amount of physical activity and movement at the Glastonbury Festival and to compare it against recommended levels. : 22 attendees wore an Actigraph activity monitor and GPS data-logger to the Glastonbury Festival.

Angiotensin type 2-receptor (AT2R) activation induces hypotension in apolipoprotein E-deficient mice by activating peroxisome proliferator-activated receptor-γ.

Angiotensin II (Ang II) modulates blood pressure and atherosclerosis development through its vascular type-1 (AT1R) and type-2 (AT2R) receptors, which have opposing effects. AT2R activation produces hypotension, and is anti-atherogenic. Targeted overexpression of AT2Rs in vascular smooth muscle cells (VSMCs) indicates that these effects are due to increased nitric oxide (NO) generation.

Chlorine gas exposure disrupts nitric oxide homeostasis in the pulmonary vasculature.

Exposure to chlorine (Cl2) gas during industrial accidents or chemical warfare leads to significant airway and distal lung epithelial injury that continues post exposure. While lung epithelial injury is prevalent, relatively little is known about whether Cl2 gas also promotes injury to the pulmonary vasculature. To determine this, rats were subjected to a sub-lethal Cl2 gas exposure (400 ppm, 30 min) and then brought back to room air.

Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents.

Ang I-converting enzyme (ACE) inhibitors are widely believed to suppress the deleterious cardiac effects of Ang II by inhibiting locally generated Ang II. However, the recent demonstration that chymase, an Ang II-forming enzyme stored in mast cell granules, is present in the heart has added uncertainty to this view. As discussed here, using microdialysis probes tethered to the heart of conscious mice, we have shown that chronic ACE inhibitor treatment did not suppress Ang II levels in the LV interstitial fluid (ISF) despite marked inhibition of ACE.