Publications by authors named "Eddie Bautista"
The combination of population growth in areas of mixed (residential, commercial, and industrial) land use along U.S. waterfronts and the increasing frequency of devastating hurricanes and storm surges has led to community fears of widespread toxic chemical contamination resulting from accidental industrial or small business releases, particularly in the aftermath of an extreme weather event, such as a hurricane.
View Article and Find Full Text PDFING-1(heMAb), a human-engineered monoclonal antibody (MAb) that specifically targets the epithelial cell adhesion molecule (Ep-CAM), kills adenocarcinoma cells in vitro and inhibits tumor growth in vivo. In the current study, we evaluated the efficacy of ING-1(heMAb) in a murine model of cancer metastases. Mice received intravenous dosing of 1 mg/kg ING-1(heMAb), twice a week, starting on day 2 or day 5.
View Article and Find Full Text PDFArticle Synopsis
- ING-1(heMAb) is a human-engineered monoclonal antibody that targets the epithelial cell adhesion molecule (Ep-CAM) and shows strong binding affinity to colon tumor cells.
- It demonstrates effective concentration-dependent lysis of various tumor cells, with optimal results at around 1 microgram/ml in laboratory tests.
- In animal studies, ING-1(heMAb) significantly reduced the growth of colon and prostate tumors, indicating its potential as a therapeutic agent against human tumors.