Topical application of amniotic membrane extract at a clinically correlated dose is effective in limiting complications in an experimental ocular alkaline burn model.

The purpose of this study is to investigate the clinical and histopathological effectiveness of topical amniotic membrane extract (AME) applied at a clinically relevant dose in an experimental corneal alkaline burn model and to compare the results with amniotic membrane transplantation (AMT) as one of the most frequently used biologically based treatment options. To create an alkaline burn model, NaOH-impregnated filter paper was applied to all rabbits for 30 s. Rabbits were divided into 3 groups: Group 1 (n = 6): AME eye drop; Group 2 (n = 6): AMT; Group 3 (n = 4): control group.

An Operational Burden Issue: Deciding on a Corneal Recipient From the Corneal Transplant Wait List for Elective Corneal Transplant.

The cornea is the outermost tissue of the eye and must be transparent to maintain good visual function. Diseases with loss of corneal transparency (ie, corneal blindness) account for 10% of blindness worldwide. The treatment of this condition is only possible with corneal transplant from corneal tissue obtained from deceased donors.