Effects of imposed and self-selected exercise on perceptual and affective responses, muscle function, quality, and functionality of strength training in older women and men: a randomized trial.

The objective of the present randomized trial was to verify the effect of twelve weeks of strength training with self-selected and imposed loads on muscle function, functionality, muscle quality, and perceptual and affective responses in elderly men and women. Twenty-four volunteers were divided into two groups of 12 individuals each: self-selected group (SS) (8 women, 4 men; mean age=66.92±6.

Oligodendrocytes go with the flow: Meningeal lymphatics promote myelin integrity.

The meningeal lymphatics system plays diverse roles in facilitating neuroimmune function at brain borders, yet its specific contribution toward glial function and homeostasis is not known. In this issue of Immunity, Das Neves et al. (2024) describe a novel role for the meningeal lymphatics in maintaining oligodendrocyte survival and myelination.

In-House Three-Dimensional Printing Workflow for Face Shield During COVID-19 Pandemic.

From the beginning of the year 2020, the world was affected by a coronavirus disease (COVID-19) pandemic, caused by SARS-CoV-2, leading to a shortage of personal protective equipment (PPE) at a global level, and thus generating exposure of health professionals to this extremely contagious virus. Within this context, the present work seeks to present an alternative for the production of face shields "face shields," in which it recommends its production "in house" through 3D printing, in principle initiated by Prusa Research, where we download your project of support of facial protectors, proceeding with printing through the 3D printer Gtmax3D Core H5. The authors produced a face shield in ABS, in a total time of 3 hours and 44 minutes.

Chronic high-fat diet affects food-motivated behavior and hedonic systems in the nucleus accumbens of male rats.

Environmental variations can influence eating and motivated behaviors, as well as the brain's feeding circuits to predisposing overweight and obesity. The identification of mechanisms through which a long-term consumption of caloric-dense palatable foods and its association with early life stress can cause neuroadaptations and possible modify motivational behaviors are relevant to elucidate the mechanisms associated with obesity. Here, we investigated the long-term effects of a chronic high-fat diet (HFD), and its interaction with early social isolation on hedonic feeding responses in adult rats.

Does Home-Based Exercise Improve the Physical Function of Prefrail Older Women?

Physical exercise is a potential intervention to revert or attenuate frailty syndrome, which may be accomplished by traditional center-based and home-based programs. This study aimed to compare the effectiveness of a home-based and center-based exercise program on frailty status, physical and muscle function of frail older women. Thirty-one frail older women were allocated in two different groups: home-based group ( = 17, 71.

Neurometabolic effects of sweetened solution intake during adolescence related to depressive-like phenotype in rats.

Objective: Exposure to artificial sweeteners, such as aspartame, during childhood and adolescence has been increasing in recent years. However, the safe use of aspartame has been questioned owing to its potentially harmful effects on the developing brain. The aim of this study was to test whether the chronic consumption of aspartame during adolescence leads to a depressive-like phenotype and to investigate the possible mechanisms underlying these behavioral changes.

Influence of Dietary Supplementation of Ensiled Devil Fish and Staphylococcus saprophyticus on Equine Fecal Greenhouse Gases Production.

The present context was designed to investigate the efficacy of devil fish (DF; Plecostomus sp.) silage and Staphylococcus saprophyticus on fermentation characteristics as well as greenhouse gases production mitigation attributes in horses. Four levels of ensiled DF at 0 (control DF0), 6 (DF6), 12 (DF12), and 18 (DF18) % were added into the diet.

Breast Hypertrophy, Reduction Mammaplasty, and Body Image.

Background: Body image dissatisfaction is one of the major factors that motivate patients to undergo plastic surgery. However, few studies have associated body satisfaction with reduction mammaplasty.

Objectives: The aim of this study was to evaluate the impact of breast hypertrophy and reduction mammaplasty on body image.

Physiological, Perceptual, and Affective Responses to Six High-Intensity Interval Training Protocols.

This study examined the extent to which different high-intensity interval training (HIIT) and sprint interval training (SIT) protocols could influence psychophysiological responses in moderately active young men. Fourteen participants completed, in a randomized order, three cycling protocols (SIT: 4 × 30-second all-out sprints; Tabata: 7 × 20 seconds at 170% ⋮O; and HIIT: 10 × 60 seconds at 90% HR) and three running HIIT protocols (4 × 4 minutes at 90%-95% HR, 5 × at v⋮O, and 4 × 1,000 meters at a rating of perceived exertion (RPE) of 8, from the OMNI-Walk/Run scale). Oxygen uptake (⋮O), heart rate, and RPE were recorded during each interval.

Increased Capacity for Work and Productivity After Breast Reduction.

Background: Breast hypertrophy is a prevalent condition among women worldwide, which can affect different aspects of their quality of life. The physical and emotional impact of breast hypertrophy may harm daily activities, including work.

Objectives: To assess the impact of reduction mammaplasty on the ability to work and productivity of women with breast hypertrophy.

Effect of a 12-week aerobic training program on perceptual and affective responses in obese women.

[Purpose] The aim of this study was to observe the effect of self-selected intensity or imposed intensity during aerobic training on perceptual and affective responses in obese women. [Subjects] The study included 26 obese women aged 30-60 years. [Methods] The subjects were randomly divided into two groups, with 13 subjects in each group: self-selected intensity and imposed intensity (10% above ventilatory threshold) groups.

Study of KRAS new predictive marker in a clinical laboratory.

Background: The presence of somatic mutations in the KRAS gene has been identified as a reliable strong negative predictor for the response to targeting the epidermal growth factor receptor (EGFR), in patients with metastatic colorectal cancer and the use of anti-EGFR monoclonal antibodies such as Cetuximab and Panitumumab is now restricted to patients with no detectable KRAS mutations. Between 30 and 40 % of colorectal cancers contain a mutated KRAS oncogene. The aim of this study was to evaluate concordance between three methods to analyze KRAS mutational status in regard to clinical testing.

[Circulating tumor cells: a new efficacy marker in the treatment of metastatic colorectal cancer].

Colorectal cancer metastasis is the result of several interacting processes at the end of which cancer cells survive in distant organs. Penetration of primary tumor cells into blood is central to the whole phenomenon of metastasis and is a common step in all cancer types. The detection of circulating tumor cells (CTC) in peripheral blood of patients with colorectal cancer could have clinical usefulness in three aspects: 1) as evidence of early dissemination, and then as a risk factor of clinical recurrence, 2) as a relevant risk factor for metastatic progression and worse prognosis, and 3) as predictive marker of response to treatment.

Measuring communication in the surgical ICU: better communication equals better care.

Background: The Joint Commission on the Accreditation of Healthcare Organizations reports that communication breakdowns are responsible for 85% of sentinel events in hospitals. Patients in surgical ICUs are the most vulnerable to communication errors. Fellows and residents are an integral part of the surgical ICU team, but little is known about resident-fellow communication and its impact on surgical ICU patient outcomes.

[Targeted therapy for cancer: anti-tyrosine kinase receptor agents].

The use of drugs to treat cancer based on molecular targets is common fact, especially those targeting kinases that are involved in the cellular signalling pathways. The anti-tyrosine receptor drugs are among the most developed, some of them having already been approved by the FDA and the EMEA for breast cancer, colorectal, lung GIST and renal cancer treatment. Although these drugs are currently focused on a single target, the future challenge is to hit several targets simultaneously, along with combined chemotherapy.