Vedolizumab-induced acute interstitial lung injury in a 39-year-old male with ulcerative colitis.

Vedolizumab, an anti-integrin antibody, is effective for moderate to severe ulcerative colitis and Crohn's disease treatment with a good safety profile due to its gut selective mechanism of action. Upper respiratory tract vedolizumab adverse events are common; however, they are mild and do not require treatment withdrawal. Herein, we present a 39-year-old patient under vedolizumab treatment for ulcerative colitis who presented acute severe interstitial lung injury that necessitated vedolizumab withdrawal and systemic steroids administration.

Dislodged biliary stent causes lower gastrointestinal hemorrhage four years postendoscopic retrograde cholangiopancreatography.

Endoscopic biliary stent placement is an efficient method for the decompression of the biliary system in various benign and malignant causes. Dislocation and stent migration is a well-known complication, with most displaced stents passing through the bowel, uneventfully. Rarely, migrated stents can be accounted for potentially life-threatening complications.

Multiparametric Magnetic Resonance Imaging of the Prostate for Tumour Detection and Local Staging: Imaging in 1.5T and Histopathologic Correlation.

Purpose: The study sought to prospectively evaluate which technique among T2-weighted images, dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted (DW) MRI, or a combination of the 2, is best suited for prostate cancer detection and local staging.

Methods: Twenty-seven consecutive patients with biopsy-proven adenocarcinoma of the prostate underwent MRI on a 1.5T scanner with a surface phased-array coil prior radical prostatectomy.

Carcinoid syndrome from a carcinoid tumor of the pancreas without liver metastases: A case report and literature review.

A carcinoid tumor of the pancreas (CTP) is a rare pancreatic neoplasm, and usually presents with carcinoid syndrome (CS). CS consists of the classic symptom triad of cutaneous flushing, diarrhea and valvular disease, and occurs in the majority of patients with liver metastases. In the present study, the patient presented with symptoms of CS.

Extrahepatic right portal vein ligation allows parenchyma-sparing en bloc resection of segments 7, 8 and 4a for liver tumors engaging the right and middle hepatic veins.

Right trisectionectomy for posterior liver tumors engaging the right and middle hepatic veins may lead to post-hepatectomy liver failure if the anticipated liver remnant is small. In such patients we developed a parenchyma-sparing one-step approach, that includes extrahepatic right portal vein ligation accompanied by en bloc resection only of segments 7, 8 and 4a and resection of the right and middle hepatic veins. The technique was applied in 3 patients with normal liver function, where according to the preoperative computed tomography the volume of segments 1, 2 and 3 ranged between 17% and 20% of the total liver volume.

Selection of recombinant anti-SH3 domain antibodies by high-throughput phage display.

Antibodies are indispensable tools in biochemical research and play an expanding role as therapeutics. While hybridoma technology is the dominant method for antibody production, phage display is an emerging technology. Here, we developed and employed a high-throughput pipeline that enables selection of antibodies against hundreds of antigens in parallel.

Inflammatory bowel disease-the role of cross-sectional imaging techniques in the investigation of the small bowel.

Background: The diagnosis of inflammatory bowel disease (IBD) in children and adolescents is based on the integration of clinical, biological, endoscopic, histological and radiological data.

Methods: The most important part of the diagnosis is the histology, which is acquired by endoscopy. Imaging of the small bowel has changed in recent years, but the imaging goals are primarily to determine the extent of small bowel involvement, assess complications and define candidates for surgery.

Reduction of motion, truncation and flow artifacts using BLADE sequences in cervical spine MR imaging.

Purpose: To assess the efficacy of the BLADE technique (MR imaging with 'rotating blade-like k-space covering') to significantly reduce motion, truncation, flow and other artifacts in cervical spine compared to the conventional technique.

Materials And Methods: In eighty consecutive subjects, who had been routinely scanned for cervical spine examination, the following pairs of sequences were compared: a) T2 TSE SAG vs. T2 TSE SAG BLADE and b) T2 TIRM SAG vs.

Using "iDose4" iterative reconstruction algorithm in adults' chest-abdomen-pelvis CT examinations: effect on image quality in relation to patient radiation exposure.

Objective: The aim of this study is to examine the effect of iDose4 hybrid iterative reconstruction algorithm (Philips Healthcare, Cleveland, OH) on radiation dose and image quality in chest–abdomen–pelvis (CAP) CT scanning of adult patients.

Methods: CAP CT examinations were performed on 99 patients with the use of the “old standard” protocol performing filtered back projection reconstruction algorithm (FBP protocol) and on 84 patients with the use of iDose4 protocol on a 64-multidetector CT. Patients were subdivided into three weight groups (Group 1, 41–60kg; Group 2, 61–90kg; and Group 3, .

Patient radiation exposure and image quality evaluation with the use of iDose4 iterative reconstruction algorithm in chest-abdomen-pelvis CT examinations.

The aim of this study is to evaluate the effect of iDose(4) iterative reconstruction algorithm on radiation dose and imaging quality at chest-abdomen-pelvis (CAP) CT examinations. Seventeen patients were considered; all patients had a previous CT scan with the standard filter back-projection (FBP) protocol and a follow-up scan with the iDose(4) protocol at the same scanner. Image noise, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were objectively calculated.

Asymptomatic omental granuloma following spillage of gallstones during laparoscopic cholecystectomy protects patients and influences surgeons' decisions: a review.

Spillage of gallstones in the peritoneal cavity during laparoscopic cholecystectomy (LC) occurs at rates varying from 5.7% to 16%. These gallstones often cannot be retrieved and can cause early and late abscesses at rates ranging from 0.

Investigative MRI cholangiopancreatography for primary sclerosing cholangitis-type lesions in children with IBD.

Objectives: The aim of the study was to estimate the frequency of primary sclerosing cholangitis (PSC)-type lesions in children with inflammatory bowel disease (IBD) by means of magnetic resonance cholangiopancreatography (MRCP), and to investigate the association between a series of easily applicable data on the one hand and the presentation of such lesions at MRCP on the other hand.

Methods: Collected demographic, laboratory, and magnetic resonance enterography data from the records of 73 children with IBD were cross-sectionally related to the MRCP-based diagnosis.

Results: Around the time of MRCP, the distribution of IBD subtypes was 64.

Use of fat suppression in R₂ relaxometry with MRI for the quantification of tissue iron overload in beta-thalassemic patients.

Purpose: To assess the performance and results of R(2) relaxometry using a fat-suppressed (FS) multiecho sequence and compare these to conventional R(2) relaxometry in estimating tissue iron overload.

Materials And Methods: Relaxation rate values (R(2)=1/T2) of the liver, spleen, pancreas and vertebral bone marrow (VBM) were estimated in 21 patients with β-thalassemia major, using a respiratory-triggered 16-echo Carr-Purcell-Meiboom-Gill (CPMG) spin-echo sequence before (R(2)) and after (R(2) FS) the application of chemically selective fat suppression.

Results: Hepatic and splenic R(2) FS values correlated with respective R(2) values (r=0.

Massive Uterine Leiomyoma in a Patient with Friedreich's Ataxia: Is There a Possible Association?

A possible association between Friedreich's ataxia (FA) and neoplastic development has been recognized. FA patients have low frataxin levels and insufficient response to oxidative stress. In these patients fibroblasts are characterized by a high rate of mutations.

Paracondylar process, a rare normal variant: the value of MRI in the diagnosis.

The paracondylar process is a rare osseous process arising at the cervicooccipital region that belongs to a large and heterogenic group of developmental abnormalities of the craniovertebral junction. We present a rare case of a paracondylar process in an 11-year-old girl, in which the diagnosis was made with the use of MRI, thereby skipping X-ray and CT scan, thus avoiding exposure of the young patient to radiation. To our knowledge, the use of MRI has not previously been reported in the investigation and diagnosis of such an abnormality.

Perforated mucinous cystadenoma of the vermiform appendix: an overview in reasoning clinical decisions.

Recent advances in the management of appendiceal mucinous neoplasms (AMN) such as peritonectomy combined with hyperthermic intraperitoneal chemotherapy have introduced new standards of care. However, many dilemmas are encountered in decision making as in the following patient. A 74-year-old woman was admitted with an appendiceal cystadenoma found in a preadmission CT scan.

Magnetic resonance imaging of the small bowel in children with idiopathic inflammatory bowel disease: evaluation of disease activity.

Background: Examinations using ionizing radiation are frequently used in the evaluation of disease activity in children affected by idiopathic inflammatory bowel disease (IBD).

Objective: To develop an MR imaging protocol without the need for fluoroscopic insertion of an enteral tube and to assess the disease activity in children with IBD.

Materials And Methods: Included in the study were 37 children (22 girls and 15 boys; age range 7-15 years, mean 11.

Assessment of iron distribution between liver, spleen, pancreas, bone marrow, and myocardium by means of R2 relaxometry with MRI in patients with beta-thalassemia major.

Purpose: To investigate the correlation between the degree of hepatic, splenic, pancreatic, vertebral bone marrow (VBM), and myocardial siderosis, as expressed by relaxation rate (R2 = 1/T2) values, in patients with thalassemia.

Materials And Methods: R2 relaxation rate values of liver, spleen, VBM, pancreas, and myocardium were estimated in 68 consecutive transfusion-dependent patients with beta-thalassemia major and 10 healthy controls using a respiratory triggered 16-echo Carr-Purcell-Meiboom-Gill (CPMG) spin echo sequence.

Results: Hepatic R2 values were significantly increased in all 68 patients; VBM, pancreatic, and myocardial R2 values were increased in 67/68, 35/47, and 47/61 patients, whereas five patients showed decreased pancreatic R2 attributed to fatty degeneration.

Embolization as an alternative treatment of insulinoma in a patient with multiple endocrine neoplasia type 1 syndrome.

Insulinoma is a rare neuroendocrine tumor, most commonly originating from the pancreas, which is either sporadic or familial as a component of multiple endocrine neoplasia type 1 syndrome (MEN1). It is characterized by increased insulin secretion leading to hypoglycemia. Surgical removal is considered the treatment of choice, with limited side effects and relatively low morbidity and mortality, both being improved by the laparoscopic procedure.

MR imaging findings of an atypical pulmonary hamartoma in a 12-year-old child.

We present the MR imaging findings in an atypical pulmonary hamartoma in a 12-year-old boy. CT showed no evidence of fat or calcifications in the tumour. It demonstrated peripheral rim enhancement on arterial-phase MR images due to a compressed respiratory epithelium, and progression to nearly homogeneous contrast enhancement on delayed-phase images.