Cold plasma is well-tolerated and does not disturb skin barrier or reduce skin moisture.

Background: Cold plasma, a new treatment principle in dermatology based on ionic discharge delivering reactive molecular species and UV-light, exhibits strong antimicrobial efficacy in vitro and in vivo. Before implementing plasma as new medical treatment tool, its safety must be proven, as well as assessing skin tolerance and patient acceptance.

Patients And Methods: We investigated the plasma effects of three different plasma sources (pulsed, non-pulsed atmospheric pressure plasma jet (APPJ) and a dielectric barrier discharge (DBD)) on the transepidermal water loss (TEWL) and skin moisture after treating the fingertips of four healthy male volunteers.

Atmospheric plasma enhances wettability and cell spreading on dental implant metals.

Objectives: Treatment regimens, which predictably support re-osseointegration of implants with peri-implantitis, are needed. Increased wettability may be an important factor for re-osseointegration. In this study, a cold atmospheric pressure gas-discharge plasma was applied to reduce water contact angles on titanium discs with different surface topography and to improve the spreading of osteoblastic cells.

Antimicrobial efficacy of non-thermal plasma in comparison to chlorhexidine against dental biofilms on titanium discs in vitro - proof of principle experiment.

Aim: Dental biofilms play a major role in the pathogenesis of peri-implant mucositis. Biofilm reduction is a pre-requisite for a successful therapy of peri-implant mucosal lesions. In this study, we evaluated the effect of three different plasma devices on the reduction of Streptococcus mutans (S.

The modified HET-CAM as a model for the assessment of the inflammatory response to tissue tolerable plasma.

Plasma medicine is a novel, highly interdisciplinary field of research. Although the knowledge is rare concerning plasma based biomedical mechanisms, correct dosages and treatment times, animal experiments have been carried out. To follow the 3Rs (reduction, refinement, replacement), it is necessary to define methods for the screening of plasma parameters.