Predicting resolution of hypoglycemia with and without dextrose infusion in newborn infant of gestational diabetic mothers.

Introduction: Neonatal hypoglycemia (NH) may lead to significant neurological impairment if left untreated. Infants of gestational diabetic mothers (IGDM) are at increased risk of early NH and need to be screened. However, it is challenging to predict management with or without intravenous dextrose once hypoglycemia is identified.

The Oro-Helical Length Accurately Predicts Endotracheal Tube Insertion Depth in Neonates.

We evaluated the reliability of the oro-helical length in predicting the ideal endotracheal tube depth in neonates and found the oro-helical length was a consistently more reliable and better predictor of the ideal endotracheal tube depth on chest radiograph than the 7-8-9 rule, especially in infants weighing ≤1500 g.

One Less Painful Procedure: Using Umbilical Cord Blood as Alternative Source to Admission Complete Blood Count.

 This study aims to evaluate the use of umbilical cord blood as an alternative to the admission complete blood count (CBC) in the well-appearing late preterm neonates admitted to the neonatal intensive care unit.  Paired umbilical cord and admission blood CBC samples from well late preterm infants were compared using a two-sample -test or analysis of variance with an unequal variance for differences in the hemoglobin, platelet counts, white blood cell, and absolute neutrophil counts.  A total of 100 infants were enrolled in the study.

Cumulative neonatal oxygen exposure predicts response of adult mice infected with influenza A virus.

An acceptable level of oxygen exposure in preterm infants that maximizes efficacy and minimizes harm has yet to be determined. Quantifying oxygen exposure as an area-under-the curve (O ) has been predictive of later respiratory symptoms among former low birth weight infants. Here, we test the hypothesis that quantifying O in newborn mice can predict their risk for altered lung development and respiratory viral infections as adults.

The role of hyperoxia in the pathogenesis of experimental BPD.

Supplemental oxygen is often used as a life-saving therapy in the treatment of preterm infants. However, its protracted use can lead to the development of bronchopulmonary dysplasia (BPD), and more recently, has been associated with adversely affecting the general health of children and adolescents who were born preterm. Efforts to understand how exposure to excess oxygen can disrupt lung development have historically focused on the interplay between oxidative stress and antioxidant defense mechanisms.