Publications by authors named "Ece Eksi"
Multiplexed tissue imaging (MTI) technologies enable high-dimensional spatial analysis of tumor microenvironments but face challenges with technical variability in staining intensities. Existing normalization methods, including z-score, ComBat, and MxNorm, often fail to account for the heterogeneous, right-skewed expression patterns of MTI data, compromising signal alignment and downstream analyses. We present UniFORM, a non-parametric, Python-based pipeline for normalizing both feature- and pixel-level MTI data.
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- The study aimed to evaluate the medium-term radiological and clinical follow-up of men with prostate lesions that tested negative on MRI-targeted biopsy (MRI-TB).
- The research included a review of records from 1,199 patients, focusing on 91 men who had Likert 4 or 5 lesions and negative biopsies, with a median follow-up time of 1.8 years.
- Findings showed that most men experienced decreased prostate-specific antigen density over time, with significant prevalence of non-cancerous pathologies observed in the biopsy results.