Impact of Malocclusions on Periodontopathogenic Bacterial Load and Progression of Periodontal Disease: A Quantitative Analysis.

(1) Periodontal disease (PD) is a globally prevalent chronic inflammatory condition, exacerbated by the dysbiosis of the oral microbiota. This study aims to evaluate the bacterial load of specific periodontopathogenic bacteria in patients with malocclusions (MAL) compared to those without. (2) Methods: Conducted at the "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania, this pilot study involved two groups: patients with MAL and PD, and patients with PD but without MAL.

Vertical Cephalometric Characteristics in Class III Malocclusions.

The phenotypic variety of Angle Class III malocclusion requires in-depth investigation of the skeletal changes from a diagnostic, prognostic and therapeutic perspective alike. The aim of our study was to evaluate the particularities of vertical cephalometric parameters of patients with Class III malocclusions, according to gender and age group. Eight parameters were analyzed on lateral cephalograms of patients with Class III malocclusions and, comparatively, on lateral cephalograms of a group with Class I malocclusions.

Assessing the morphological characteristics of teeth and dental arches as potential predictors of dental crowding.

Background And Aims: The early detection of dental crowding and its potential for aggravation is important during the clinical examination of mixed dentition patients, and these desiderates can be addressed by including among the clinically assessed items a series of accessible morphological characteristics of teeth and dental arches. The present study investigates possible correlations between morphological features of permanent teeth, widths of dental arches, and the onset of dental crowding during mixed dentition.

Methods: A selected group of 100 class I dental casts on mixed dentition was analyzed.

Perceptions and Expectations of Academic Staff in Bucharest towards the COVID-19 Pandemic Impact on Dental Education.

Dental education was severely challenged by the COVID-19 pandemic worldwide. The evaluation of the viewpoint of the dental teachers of the Faculty of Dentistry at "Carol Davila" University of Medicine and Pharmacy in Bucharest, Romania, on these exceptional circumstances' consequences was the objective of this paper. A cross-sectional study was conducted in April 2022, on the academic staff who reported their perceptions of the emotional and educational impact of the pandemic by completing a Google Forms questionnaire.

Reducing Friction in Orthodontic Brackets: A Matter of Material or Type of Ligation Selection? In-Vitro Comparative Study.

(1) Background: Orthodontic appliances have changed and improved with the increasing demand for orthodontic treatment of the general population. Patients desire for shorter orthodontic treatments and for the wearing of more aesthetic devices has led to the technological development of orthodontic brackets; these were manufactured from aesthetic materials (ceramics, composite polymers) and presented different designs regarding the way archwires are ligated to the bracket. The aim of this study was to determine whether there were any differences between the static frictional forces generated by stainless steel (metallic) and polycrystalline alumina (ceramics) conventional and self-ligating brackets.

Hopeless tooth? Prognosis and comprehensive treatment. A case report.

A hopeless tooth from a periodontal point of view, with severe bone resorption, mobility and abnormal tooth migration, is often extracted. In advanced cases, function and esthetics are impaired, and an interdisciplinary treatment is requested. Retaining or not these teeth is based on clinician judgment.

Performance Evaluation on Rotary Preparation of Root Canal by Beginner Operators.

This study aims to analyze the performance of rotary root canal preparation, conducted by beginner operators (students). After acquiring the necessary skills involved in applying endodontic preparation techniques on extracted teeth, all students from a cohort learned to use ProTaper Universal files (Dentsply Maillefer). The preclinical training had several stages.

Autophagy, One of the Main Steps in Periodontitis Pathogenesis and Evolution.

Periodontitis represents a complex inflammatory disease that compromises the integrity of the tooth-supporting tissue through the interaction of specific periodontal pathogens and the host's immune system. Experimental data help to outline the idea that the molecular way towards periodontitis initiation and progression presents four key steps: bacterial infection, inflammation, oxidative stress, and autophagy. The aim of this review is to outline the autophagy involvement in the pathogenesis and evolution of periodontitis from at least three points of view: periodontal pathogen invasion control, innate immune signaling pathways regulation and apoptosis inhibition in periodontal cells.

A Review on the Biocompatibility of PMMA-Based Dental Materials for Interim Prosthetic Restorations with a Glimpse into their Modern Manufacturing Techniques.

This paper's primary aim is to outline relevant aspects regarding the biocompatibility of PMMA (poly(methyl methacrylate))-based materials used for obtaining interim prosthetic restorations, such as the interaction with oral epithelial cells, fibroblasts or dental pulp cells, the salivary oxidative stress response, and monomer release. Additionally, the oral environment's biochemical response to modern interim dental materials containing PMMA (obtained via subtractive or additive methods) is highlighted in this review. The studies included in this paper confirmed that PMMA-based materials interact in a complex way with the oral environment, and therefore, different concerns about the possible adverse oral effects caused by these materials were analyzed.

Elderly Patients' Perception of Previewing the Prosthetic Treatment Outcome.

The demographic statistics indicate that, with the industrial development and the advances in the medical field, the average life of the population has started to increase significantly; consequently, the needs of treatments in geriatric dentistry are becoming more and more significant. The purpose of this study was to evaluate patients' perception of diverse techniques used to obtain previews for final fixed prosthetic restorations: digital smile design (DSD), wax-up, indirect mock-up, temporary restorations, Computer-Aided Design (CAD). A focus group that included 11 participants, all of them geriatric patients, was formed; patients were invited to respond to a set of seven questions before and after various previsualization methods were applied.

Alveolar blood clots and platelet-rich fibrin induce fibroblast proliferation and migration.

Wound healing process comprises a complex network of cells and molecules that are regulated in order to pursue tissue regeneration. Our study focused on the capacity of alveolar blood clots (ABCs), platelet-rich fibrin (PRF) and plasma rich in growth factors (PRGF) to induce fibroblasts proliferation and migration as a measure of alveolar regeneration. Using cellular impedance with xCELLigence technology we quantified the proliferation and the migration capacity of L929 fibroblast standard cell line in the presence of 4 different ABCs and 3 different PRFs harvested from healthy individuals during standard tooth extraction.

Variation in Expression of Inflammation-Related Signaling Molecules with Profibrotic and Antifibrotic Effects in Cutaneous and Oral Mucosa Scars.

Wound healing is a complex biologic process evolving in three phases: inflammation, proliferation, and tissue remodeling controlled by numerous growth factors and cytokines. Oral mucosa wounds heal with significantly less important scars with less numerous macrophages and mast cells and more numerous myofibroblasts than cutaneous counterparts. We analyzed 32 cutaneous and 32 oral mucosa scars for TGFbeta1, TGFbeta2, TGFbeta3, TNFalpha, PDGF BB and FGF1 expression in mesenchymal cells, endothelial cells, macrophages, and multinucleated giant cells.

Common and unusual dental development abnormalities in a patient with bicuspid aortic valve.

Bicuspid aortic valve (BAV) is the most common congenital abnormality of the heart. In this condition, instead of three cusps, the aortic valve has two cusps. Children with congenital heart diseases are at increased risk of developing oral diseases, such as: higher number of decayed teeth, developmental anomalies, periodontal disease, malocclusion, dental crowding, as well as susceptibility to develop infective endocarditis from bacteremia caused by chronic poor oral health.

An application of microscopic investigation on extracted premolar with dyschromia, related to the components of endodontic sealer.

The aim of this study was an assessment of the overall optical characteristics changes in volume of the dentin, after the diffusion of the chemical components included in the sealer throughout the endodontic space, in order to demonstrate the discoloration effect of the endodontic sealer on tooth crown of a recently extracted maxillary premolar. Thin sections were studied using the polarized transmitted light microscopy and under a stereomicroscope, operating in transmitted light and reflected light. There were performed serial images of magnitude 40×.

An optical investigation of dentinal discoloration due to commonly endodontic sealers, using the transmitted light polarizing microscopy and spectrophotometry.

The aim of this study was to establish the degree of tooth crown staining by commonly used endodontic sealers. Crown discolorations by tooth canal sealers [AH Plus (Dentsply DeTrey Gmbh, Konstanz, Germany); Endofill (Produits Dentaires SA, Vevey, Switzerland); Apexit (Dentsply DeTrey Gmbh, Konstanz, Germany); and MTA Fillapex (Angelus, Londrina, Brazil)] were tested on extracted human premolars. The samples were divided into five groups of five samples each, after root canal sealing.

Upper airway cavities morphologic features in facial asymmetries.

Facial asymmetries have an important impact on the cranio-facial structures morphology, being the result of the genetic, environmental and dysfunctional factors and their impact on the dento-maxillary complex. Asymmetries can be identified in all craniofacial structures, including the upper airway cavities. Craniofacial asymmetries can influence general growth and development by altering the respiratory function.

Considerations on morphological abnormalities of permanent teeth in children with cleft lip and palate.

Oral clefts are commonly associated with dental anomalies of number, size, shape, structure, position and eruption affecting both dentitions. Dental malformations may affect the development, growth and functions of the dento-maxillary apparatus (chewing, aesthetics, speech). The purpose of this paper was to assess the dental morphological variations in a group of patients with cleft lip and/or palate (CLP), as compared with a group of healthy subjects.

Pharmacokinetic profile evaluation of di-μ-hydroxo-bis(quercetinatooxovanadium(IV)) complex.

The present study was designed to evaluate the pharmacokinetic (PK) properties of di-μ-hydroxo-bis(quercetinatooxovanadium(IV) (HOBQOV) complex, with hypoglycemic and hypolipidemic properties, in rats after a single i.p. dose of 100 mg/kg b.

Influence of orthodontic treatment on oral streptococci.

Unlabelled: Objective of this study is to evaluate the changes of the oral microbial flora, concentrating on the oral streptococci, after the first 3 and 6 months of orthodontic treatment.

Materials And Methods: 40 patients, aged 7-17, that presented for orthodontic treatment between April and September 2010 in the Department of Orthodontics and Dento-Facial Orthopedics of "Carol Davila" University of Medicine and Pharmacy, Bucharest have been selected. According to the protocol, coronary and subgingival plaque was collected from the dental surface before starting any orthodontic treatment (T0), 3 months after wearing orthodontic appliances (T1) and 6 months after wearing orthodontic appliances (T2).

Undesirable dental hard tissue effects hypothetically linked to orthodontics - a microscopic study.

Like any other medical intervention, the orthodontic treatment may have, besides the positive effects, also unwanted secondary consequences. The aim of this study was to evaluate the changes present in dental hard tissue associated with orthodontic treatment. The stereo-microscopic ex vivo analysis was performed on two sets of maxillary first premolars undergoing orthodontic treatment for a long period of time (12 and 23 months); five teeth with other clinical situations were used as controls.

Orthodontically induced root resorption correlated with morphological characteristics.

Unlabelled: Orthodontically induced root resorption is an irreversible process that can have medical, ethical and legal implications.

Aim: The objective of this research was to identify morphological risk factors, in order to prevent it.

Material And Methods: We realized a retrospective study on 50 patients and made correlation between the prevalence and gravity of radiological identified root resorption and multiple biological and anatomical features.

Prevention perspective in orthodontics and dento-facial orthopedics.

In the present context of the public health directions, considering WHO main objective, that "all people of the world could reach the highest possible health level", in medicine, the accent is put on prevention. In spite of the important progresses achieved in orthodontics field, the treatment still remains a symptomatic one. In this context, we must ask ourselves what are the prevention theoretical and practical coordinates in orthodontics, which measures are available or could be elaborated for preventing the malocclusions development.

[Echocardiographic evaluation of left ventricular diastolic dysfunction in patients with diabetes mellitus].

The presence of diabetic cardiomyopathy, without any sign of hypertension, valvular or coronary artery disease, is related to diastolic dysfunction, an early sign of diabetic heart muscle disease. Doppler echocardiography evaluation should be performed for all patients with type 2 diabetes mellitus and microalbuminuria, in order to obtain a better management of this metabolic disease.

[Acrylic resin reinforcement with metallic and nonmetallic inserts].

In the current use of acrylic resin for removable dentures and orthodontic treatments we are frequently facing the fact of base fracture. The repairing of this, determine most of the time, discomfort of the patient, by excluding the prosthetic device, affecting the treatment, loosing patient's time, doctor's time, implying the dental laboratory and extra expenses. The causes of fractures are many, from clinical cases with some specific anatomic and functional particularities, or parafunctional, to the incorrect designing, manufacturing or wearing of the prosthetic part, being connected with the materials characteristics.

[Canine tooth transposition study on a group of patients orthodontically treated].

The dental transposition is an eruption anomaly, which occurs in this process towards the final stage and that represents the switching of 2 teeth that are next to each other. The tooth that most often is involved in transposition is the canine tooth, most frequently the upper one, which switches places either with the first premolar either with the lateral incisor. Under a clinical aspect, the transposition can be total (complete) or partial (incomplete), the latter reported both for crowns and roots.