Electron microscopic evaluation of the effect of therapeutic silicone hydrogel lenses on the limbal area.

Purpose: To investigate the effects of high-permeability silicone hydrogel contact lenses used for therapeutic purposes on limbal cells, inflammation, and neovascularization.

Methods: Bullous keratopathy was induced by injection of 0.05% benzalkonium chloride into the anterior chamber of 20 anesthetized rabbit eyes.

Life-threatening mediastinal-retroperitoneal hemorrhage in a child with moderate hemophilia A and high inhibitor titer: successful management with recombinant activated factor VII.

The authors describe an 11-year-old boy with hemophilia A and high titer inhibitor who developed a life-threatening mediastinal-retroperitoneal hemorrhage. Chest CT showed a large hematoma beginning in the retrotracheal area, filling the mediastinum, compressing the carina, and extending retroperitoneally up to the kidneys. As the surgical approach has a high mortality rate, the authors chose a more conservative approach initially and obtained excellent bleeding control with recombinant activated factor VII without the need for surgical intervention.