Investigation of Antioxidant, Antibacterial, and Anticancer Activities, and Molecular Modeling Studies of Berberis crataegina Fruit Extract.

This study was conducted to determine the total antioxidant capacity (TAC), anti-quorum sensing (QS) potential, and anticancer activity of extracts obtained from Berberis crataegina fruits by the maceration method. Moreover, the mode of action for the antioxidant activity was explored by molecular modeling. For this purpose, we performed 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), ferric reducing antioxidant power (FRAP), and cupric ion reducing antioxidant capacity (CUPRAC) methods to measure the antioxidant ability of the extracts.

Anti-quorum sensing activity in a PA01 of benzimidazolium salts: electronic, spectral and structural investigations as theoretical approach.

Quorum sensing (QS) is a system used in the expression of virulence factors by many pathogenic bacteria, and blockage of the system is seen as a new and effective strategy in combating with resistant bacteria. The inhibition effects of two benzimidazolium salts, namely 1-(2-methylbenzonitrile)-3-benzylbenzimidazolium bromide () and 1-(-methylphthalimide)-3-(4-methylbenzyl)benzimidazolium bromide (), on quorum sensing-related virulence factors such as pyocyanin, elastase, biofilm formation and swarming motility, which is an opportunistic pathogen a PA01, were investigated in this study. The results show that the compound has a significant inhibition on biofilm formation with 94%.