Association between CYP19A

Acne vulgaris (AV) is a common skin disease that causes physical and psychological problems for the affected individual. In addition to systemic changes in hormone levels, overproduction of local steroids, especially androgens are associated with AV. Cytochrome (CYP) 19 is involved in the synthesis of estrogens.

Morpho-Physiological and Genomic Evaluation of Species Reveals Regional Maladaptation to Cold Stress.

Climate change may have unpredictable effects on the cold hardiness of woody species planted outside of their range of origin. Extreme undulations in temperatures may exacerbate susceptibility to cold stress, thereby interfering with productivity and ecosystem functioning. L.

Structural insights for rational design of new PIM-1 kinase inhibitors based on 3,5-disubstituted indole derivatives: An integrative computational approach.

Proviral integration Moloney virus (PIM) 1, 2, and 3 kinases are a family of constitutively active serine/threonine kinases that are involved in a number of signaling pathways important to cancer cells. Their overexpression in a variety of human hematopoietic malignancies and solid tumors suggest that inhibition of PIM signaling could provide patients with therapeutic benefit. In this study, a series of 3,5-disubstituted indole derivatives have been systematically studied using three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis, molecular docking simulation, and partial least-squares (PLS) analysis methods to explore the influence of the structural characteristics on the inhibitory activity and use them to propose novel bioactive molecules.

The relationship of indoor radon gas concentration with multiple sclerosis: a case-control study.

This case-control study aimed to investigate the relationship of indoor radon gas concentration and residential building characteristics with mental health with multiple sclerosis (MS) in Yazd City, Iran. The participants included 45 patients with MS and 100 healthy individuals. The participants' socio-economic status and residential building characteristics were investigated using a questionnaire.

Identification of new potential cyclooxygenase-2 inhibitors: insight from high throughput virtual screening of 18 million compounds combined with molecular dynamic simulation and quantum mechanics.

The cyclooxygenase isoenzymes (COX-1 and COX-2) have a critical role in inflammation, fever, and pain. In contrary to COX-1, COX-2 is specifically expressed in inflamed tissues. Because of the subtle difference between both enzyme active sites, targeting COX-2 represents an efficient strategy for the development of novel inhibitors against inflammation with fewer side effects.

Synthesis and Characterization of Novel Pyridine Periodic Mesoporous Organosilicas and Its Catalytic Activity in the Knoevenagel Condensation Reaction.

The preparation of novel organic-inorganic hybrid mesoporous organosilica containing pyridinedicarboxamide functional groups uniformly distributed inside the nanostructured pore walls has been addressed. The mesoporosity and uniformity of the synthesized nanomaterials were characterized by different techniques such as nitrogen adsorption/desorption measurements and powder X-ray diffraction (PXRD). Additionally, the presence of the pyridinedicarboxamide in the pore walls of the nanomaterials was assessed by Fourier-transform infrared spectroscopy (FT-IR), as well as Si and C solid-state cross-polarization and magic angle spinning nuclear magnetic resonance (CP/MAS-NMR).

Search for production of four top quarks in final states with same-sign or multiple leptons in proton-proton collisions at .

The standard model (SM) production of four top quarks ( ) in proton-proton collisions is studied by the CMS Collaboration. The data sample, collected during the 2016-2018 data taking of the LHC, corresponds to an integrated luminosity of 137 at a center-of-mass energy of 13 . The events are required to contain two same-sign charged leptons (electrons or muons) or at least three leptons, and jets.

The Insulin-like Growth Factor-1 (G>A) and 5,10-methylenetetrahydrofolate Reductase (C677T) Gene Variants and the Serum Levels of Insulin-like Growth Factor-1, Insulin, and Homeostasis Model Assessment in Patients with .

Background & Objective: To find an association between gene variants of insulin-like growth factor-1 (IGF-1) and 5,10-methylenetetrahydrofolate reductase (MTHFR) with the risk of acne vulgaris (AV).

Methods: In a case-control study, we investigated 150 AV patients and 148 healthy individuals (aged 18-25 years) for the IGF-1 G>A and MTHFR C677T polymorphisms, as well as the serum levels of IGF-1, insulin, and the homeostasis model assessment of insulin resistance (HOMA-IR). The serum biochemical parameters and the genotypes of IGF-1 G>A and MTHFR C677T were detected by using appropriate kits and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods, respectively.

Microwave Differential Frequency Splitting Sensor Using Magnetic-LC Resonators.

A differential microwave permittivity sensor and comparator is designed using a microstrip transmission line loaded with a magnetic-LC resonator. The microstrip transmission line is aligned with the electric wall of the resonator. The sensor shows a single transmission zero, when it is unloaded or loaded symmetrically on both halves.

Regional Metastasis in Head and Neck Cutaneous Squamous Cell Carcinoma: An Update on the Significance of Extra-Nodal Extension and Soft Tissue Metastasis.

Background: Soft tissue metastases (STMs) are reported to predict worse prognosis than extra-nodal extension (ENE) in metastatic head and neck cutaneous squamous cell carcinoma. This study aimed to update the authors' previous analysis of STM in a larger series.

Methods: The study analyzed 535 cases of consecutive cSCC metastatic to the parotid and/or neck treated by primary surgical resection between 1987 and 2007.

Drug-induced myocardial dysfunction - recommendations for assessment in clinical and pre-clinical studies.

: Drug-induced myocardial dysfunction is an important safety concern during drug development. Oncology compounds can cause myocardial dysfunction, leading to decreased left ventricular ejection fraction and heart failure via several mechanisms. Cardiovascular imaging has a major role in the early detection and monitoring of cardiotoxicity.

Search for Supersymmetry with a Compressed Mass Spectrum in Events with a Soft τ Lepton, a Highly Energetic Jet, and Large Missing Transverse Momentum in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for supersymmetry in events with an experimental signature of one soft, hadronically decaying τ lepton, one energetic jet from initial-state radiation, and large transverse momentum imbalance is presented. These event signatures are consistent with direct or indirect production of scalar τ leptons (τ[over ˜]) in supersymmetric models that exhibit coannihilation between the τ[over ˜] and the lightest neutralino (χ[over ˜]_{1}^{0}), and that could generate the observed relic density of dark matter. The data correspond to an integrated luminosity of 77.

Comparing THMs level in old and new water distribution systems; seasonal variation and probabilistic risk assessment.

Trihalomethanes (THMs) in drinking water are associated with many chemical parameters in water. However, the available evidence on the relationship between physical parameters of the water distribution system (WDS) and THMs is still scarce; therefore, this study aimed to compare the THMs concentration in the old and new WDS in Yazd, Iran. Moreover, we investigated the seasonal trend and health risk assessment of exposure to THMs through ingestion, dermal, and inhalation pathways.

Efficient degradation of microcystin-LR by BiVO/TiO photocatalytic nanocomposite under visible light.

Microcystin-Leucine Arginine (MC-LR) is one of the most studied cyanotoxins due to its toxicity and abundant that cause health hazards for humans through of the drinking water. In this study, BiVO/TiO nanocomposite was synthesized by hydrothermal method and employed for the removal of MC-LR. The characteristics of the catalysts were determined by FESEM, XRD and FTIR spectra.

Improved degradation of n-hexane vapours using a hybrid system, a photoreactor packed with TiO coated-scoria granules and a multilayer biofilter.

Biofiltration of hydrophobic and/or recalcitrant volatile organic compounds such as n-hexane is imperfect. In the present study, we applied a hybrid system consisting of a photoreactor packed with scoria granules coated with TiO and a biofilter to improve the removal efficiency of n-hexane from the air stream. The experimental results showed that the hybrid system provided higher removal efficiencies than the single biofilter process with an inlet n-hexane concentration range of 0.

Searches for physics beyond the standard model with the variable in hadronic final states with and without disappearing tracks in proton-proton collisions at .

Two related searches for phenomena beyond the standard model (BSM) are performed using events with hadronic jets and significant transverse momentum imbalance. The results are based on a sample of proton-proton collisions at a center-of-mass energy of , collected by the CMS experiment at the LHC in 2016-2018 and corresponding to an integrated luminosity of 137 . The first search is inclusive, based on signal regions defined by the hadronic energy in the event, the jet multiplicity, the number of jets identified as originating from bottom quarks, and the value of the kinematic variable for events with at least two jets.

Extraction and validation of a new set of CMS pythia8 tunes from underlying-event measurements.

New sets of CMS underlying-event parameters ("tunes") are presented for the pythia8 event generator. These tunes use the NNPDF3.1 parton distribution functions (PDFs) at leading (LO), next-to-leading (NLO), or next-to-next-to-leading (NNLO) orders in perturbative quantum chromodynamics, and the strong coupling evolution at LO or NLO.

MicroRNA Tough Decoy Knockdowns miR-195 and Represses Hypertrophy in Chondrocytes.

Cartilage hypertrophy is a condition in which the cells are completely differentiated, and new morphological changes and mineralization prevent proper cellular functions. The occurrence of hypertrophy during differentiation fails current regenerative strategies for treatment. Strategies to minimize hypertrophy in chondrocytes are categorized into two levels of protein and gene.

Search for Physics beyond the Standard Model in Events with Overlapping Photons and Jets.

Results are reported from a search for new particles that decay into a photon and two gluons, in events with jets. Novel jet substructure techniques are developed that allow photons to be identified in an environment densely populated with hadrons. The analyzed proton-proton collision data were collected by the CMS experiment at the LHC, in 2016 at sqrt[s]=13  TeV, and correspond to an integrated luminosity of 35.

Artificial intelligence, robotics and eye surgery: are we overfitted?

Eye surgery, specifically retinal micro-surgery involves sensory and motor skill that approaches human boundaries and physiological limits for steadiness, accuracy, and the ability to detect the small forces involved. Despite assumptions as to the benefit of robots in surgery and also despite great development effort, numerous challenges to the full development and adoption of robotic assistance in surgical ophthalmology, remain. Historically, the first in-human-robot-assisted retinal surgery occurred nearly 30 years after the first experimental papers on the subject.

Measurement of the average very forward energy as a function of the track multiplicity at central pseudorapidities in proton-proton collisions at .

The average total energy as well as its hadronic and electromagnetic components are measured with the CMS detector at pseudorapidities in proton-proton collisions at a centre-of-mass energy . The results are presented as a function of the charged particle multiplicity in the region . This measurement is sensitive to correlations induced by the underlying event structure over a very wide pseudorapidity region.

Measurements of triple-differential cross sections for inclusive isolated-photon+jet events in collisions at .

Measurements are presented of the triple-differential cross section for inclusive isolated-photon+jet events in collisions at TeV as a function of photon transverse momentum ( ), photon pseudorapidity ( ), and jet pseudorapidity ( ). The data correspond to an integrated luminosity of that probe a broad range of the available phase space, for and , , , and jet transverse momentum, , > 25 . The measurements are compared to next-to-leading order perturbative quantum chromodynamics calculations, which reproduce the data within uncertainties.

Highly Sensitive Determination of Bisphenol A in Bottled Water Samples by HPLC after Its Extraction by a Novel Th-MOF Pipette-Tip Micro-SPE.

In this study, a novel thorium metal organic framework was synthesized, characterized and used as a sorbent for very efficient pipette tip micro solid-phase extraction of bisphenol A in bottled drinking water samples using high-performance liquid chromatography as detecting instrument. Parameters which influence extraction efficiency such as pH, sample volume, amount of sorbent, type and volume of eluent, number of aspirating and dispensing cycles for extraction and elution, and volume of the sample solution were studied and optimized. A linear calibration curve was obtained in the range of 0.