Publications by authors named "Ebony D Webber"
Article Synopsis
- A study found age-related brain changes in two older polar bears, including amyloid plaques and tangles, similar to those seen in Alzheimer's disease in humans.
- The bears, aged 28 and 37, scored high on various assessment metrics related to neurodegeneration, indicating significant brain pathology.
- The research applies standardized guidelines for evaluating neurodegenerative changes, highlighting the potential for future comparative studies on aging in wildlife.
Parkinson's disease (PD) is associated with aberrant innate immune responses, including microglial activation and infiltration of peripheral myeloid cells into the central nervous system (CNS). Methods to investigate innate immune activation in PD are limited and have not yet elucidated key interactions between neuroinflammation and peripheral inflammation. Translocator protein 18 kDa (TSPO) PET is a widely evaluated imaging approach for studying activated microglia and peripheral myeloid lineage cells in vivo but has yet to be fully explored in PD.
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