Relationship between of blood flow, glucose metabolism, protein synthesis, glucose and ATP content in experimentally-induced glioma (RG1 2.2) of rat brain.

In experimental RG1 2.2 glioma of rat brain, local blood flow, glucose utilization, protein synthesis, glucose and ATP content were measured by means of triple tracer autoradiography and bioluminescence technique, respectively, to determine hemodynamic and metabolic thresholds for local tumor energy failure. Perfusion thresholds were estimated at tumor blood flow values of 69.

Dexamethasone does not influence infarct size but causes haemorrhage in baboons with cerebral infarcts.

15 baboons with permanent occlusion of the left MCA were randomly treated with dexamethasone (n = 8; 1 mg/kg day) or 0.9% NaCl (n = 5). Dexamethasone did not reduce the resulting infarct size.

Brain metastasis of an invasive thymoma.

A rare case of a thymoma metastatic to brain is reported. This tumor was localized intraoperatively with the use of transdural ultrasound imaging, and gross total resection was accomplished. Radiation therapy was administered to both brain and mediastinum.

Gliomatosis cerebri: clinical and histological findings.

The clinical and pathological data of ten patients with gliomatosis cerebri are compared with 48 well documented cases from the literature. The most striking clinical findings were behavioural and mental changes, seizures, motor weakness and headaches. Though diagnostic techniques have gained in sophistication, the clinical diagnosis of gliomatosis cerebri remains difficult.

MR imaging in adrenoleukomyeloneuropathy.

A 54-year-old patient with clinical and biochemical features of the adrenoleukomyeloneuropathy-complex is reported. Although CT was essentially normal, magnetic resonance (MR) showed areas of prolonged T1 and T2 values in the corpus callosum, around the trigones of the lateral ventricles, in the internal capsules, in the pons, and in the cervical spinal cord. This case report indicates that MR is better suited than CT to detect demyelination of the cerebral white matter and of descending tracts.

Review and case report: primary melanoblastosis of the leptomeninges.

A case of primary diffuse leptomeningeal melanoblastosis in a 46-year-old male is reported. His symptoms included headaches, transient hemiparesis, epileptic seizures and a progressive psychosyndrome. CT brain scans showed a slight enhancement of density in the subarachnoidal space.

[Spontaneous pontine hemorrhage].

Data from 11 observed patients with spontaneous pontine haemorrhages were compared to the findings in 235 cases reported in 9 studies. Causes of pontine haemorrhages which have an incidence of 2 to 4/100 000/year include hypertension, vascular malformations (a.v.

[Cerebellar hemorrhage from an arteriovenous angioma during angiography].

In a 53-year-old man in whom computed tomography and cerebral angiography did not reveal a bleeding source in the initial stage, cerebral angiography was repeated 3 weeks later. After injection of 3 ml contrast medium into the commune carotid artery a mid brain syndrome developed and the patient died on the sequels of brain stem compression. Autopsy revealed a large cerebellar hemorrhage originating from an arteriovenous malformation.

Neuronal injury following permanent middle cerebral artery occlusion in cats.

The border of a chronic infarct is sharply demarcated. We found in our investigation, however, that this is merely a macroscopic diagnosis and does not say anything about the structure of the tissue and the content of morphologically preserved neurons in the marginal zones. In six cats the left cerebral artery was permanently occluded.

Flow and neuronal density in tissue surrounding chronic infarction.

In 6 cats, cerebral infarction was produced by transorbital occlusion of the left middle cerebral artery (MCA). Five animals developed typical cortical infarcts. Eight weeks later, cerebral blood flow (CBF) was determined by 14C-iodoantipyrine autoradiography and the number of intact neurons was counted histologically.

[Morphological findings in experimentally induced gliomas in cats].

Gliomas were produced in 60 cats by stereotactic xenotransplantation of a rat glioma clone RG2. The animals were divided into two groups. One group was killed without any therapy 21 days after cell transplantation.

The fine structure of cells in astrocytomas of various grades of malignancy.

87 gliomas were studied electron microscopically. 9 tumors were excluded from the series as mixed gliomas. The ultrastructure of the cell cytoplasm was considered particularly relevant for the present study.

[Spontaneous intracerebellar haematoma in childhood (author's transl)].

Spontaneous cerebellar haemorrhage accounts for 10% of all intracranial spontaneous haematomas. It is a disease which principally affects patients over middle age, and it is rare in childhood. To twelve cases previously reported we now add a further three.