Simulation and validation of residual deformations in additive manufacturing of metal parts.

Selective laser melting (SLM) is gaining increasing relevance in industry. Residual deformations and internal stresses caused by the repeated layerwise melting of the metal powder and transient cooling of the solidified layers still presents a significant challenge to the profitability and quality of the process. Excessive distortions or cracking may lead to expensive rejects.

Implications of long-term care capacity response policies for an aging population: a simulation analysis.

Introduction: The demand for long-term care (LTC) services is likely to increase as a population ages. Keeping pace with rising demand for LTC poses a key challenge for health systems and policymakers, who may be slow to scale up capacity. Given that Singapore is likely to face increasing demand for both acute and LTC services, this paper examines the dynamic impact of different LTC capacity response policies, which differ in the amount of time over which LTC capacity is increased, on acute care utilization and the demand for LTC and acute care professionals.

Simulating the impact of long-term care policy on family eldercare hours.

Objective: To understand the effect of current and future long-term care (LTC) policies on family eldercare hours for older adults (60 years of age and older) in Singapore.

Data Sources: The Social Isolation Health and Lifestyles Survey, the Survey on Informal Caregiving, and the Singapore Government's Ministry of Health and Department of Statistics.

Study Design: An LTC Model was created using system dynamics methodology and parameterized using available reports and data as well as informal consultation with LTC experts.

Future living arrangements of Singaporeans with age-related dementia.

Background: With rapid aging, Singapore faces an increasing proportion of the population with age-related dementia. We used system dynamics methodology to estimate the number and proportion of people with mild, moderate, and severe dementia in future years and to examine the impact of changing family composition on their likely living arrangements.

Methods: A system dynamics model was constructed to estimate resident population, drawing birth and mortality rates from census data.

Crossflow filtration for CHO cell separation by microfiltration using crossflow systems.

Chinese Hamster Ovary (CHO) cells are used for fermentation of high value proteins in the pharmaceutical- and biotechnology industry. During the fermentation process the cells are grown under specific conditions in a defined media. The CHO cells produce extra cellular proteins.

Comparison of intermittent and continuously nebulized albuterol for treatment of asthma in an urban emergency department.

Study Objective: To compare continuously nebulized albuterol with intermittent bolus nebulization of albuterol.

Design: Consecutive block enrollment in groups of ten to continuous or intermittent therapy.

Setting: Urban emergency department.

Antigen-induced histamine-release in diagnosis of allergy.

Antigen-induced histamine-release from basophils was evaluated in 12 patients with hypersensitivity to grass, 14 patients with hypersensitivity to grains and 14 patients with hypersensitivity to insect-venom using a test with very high sensitivity. - Histamine-release upon stimulation with antigen was found in all patients with grass-hypersensitivity, in 12 of 14 patients with grain-hypersensitivity and in 10 of 14 patients with insect-venom-hypersensitivity. Additionally performed determination of total-IgE proved less valuable, whereas specific-IgE and skin-test showed a higher validity in hypersensitivity to grains.