Effects of FESS and additional fluticasone propionate nasal drops on psychological well-being in nasal polyposis with asthma.

Conclusion: A combined therapy of fluticasone propionate nasal drops (FPND) and functional endoscopic sinus surgery (FESS) can improve quality of life (QoL). When compared with prior data, the results imply that a generic measure of psychological aspects of QoL may be better than measures of respiratory symptoms and clinical parameters to capture a patient's perception of the disease and its treatment.

Objective: To better understand effects of FPND and FESS on generic QoL.

Effects of smell loss on daily life and adopted coping strategies in patients with nasal polyposis with asthma.

Conclusions: Results from prior studies of quality of life (QoL) in heterogeneous patient groups (regarding disorder type and etiology) with olfactory disorders may be useful also for understanding QoL in homogeneous patient groups. Diagnosis and treatment of smell loss should be given high priority in polyposis with asthma, and coping strategies can be suggested to these patients.

Objectives: To investigate the effects of smell loss on daily life and coping strategies in patients with smell loss without dysosmia and with nasal polyposis with asthma as the only primary etiology, and to compare these results with those from a prior study of a patient group with heterogeneous olfactory disorders and etiology.

Pheromone signal transduction in humans: what can be learned from olfactory loss.

Because humans seem to lack neuronal elements in the vomeronasal organ (VNO), many scientists believe that humans are unable to detect pheromones. This view is challenged by the observations that pheromone-like compounds, 4,16-androstadien-3-one (AND) and oestra-1,3,5(10),16-tetraen-3-ol (EST), activate the human hypothalamus. Whether these activations are mediated via VNO, venous blood or olfactory mucosa is presently unknown.

A randomized prospective study comparing medical and medical-surgical treatment of nasal polyposis by CT.

Conclusions: CT of the sinuses showed long-lasting improvement in the total and CT scores of the osteomeatal complex (OMC) after combined surgical and corticosteroid treatment as compared with medical treatment alone. However, the correlations between the improved CT scores and the patients' symptoms, olfactory thresholds or polyp scores were generally not significant.

Objective: To evaluate CT scans as a method for comparing the effect of medical treatment versus combined surgical and medical treatment of nasal polyposis.

Consequences of olfactory loss and adopted coping strategies.

Unlabelled: The aims of this study were to investigate the effects of loss of smell as regards the quality of life and the coping strategies used.

Methods: Seventy-two patients with anosmia (46%) or hyposmia (54%) filled in the validated Multi-Clinic Smell and Taste Questionnaire, the validated General Well-being Schedule (GWBS), and answered other questions shown to be of good validity.

Results: Several kinds of negative effects, risks associated with the loss, interference with daily routines and deteriorations in well-being were common.

Placebo-controlled, randomized, double-blind study evaluating the efficacy of fluticasone propionate nasal spray for the treatment of patients with hyposmia/anosmia.

Objective: To compare the effect on olfaction of topical glucocorticoid treatment versus placebo given for an extended period in addition to oral short-term glucocorticoids in patients with anosmia/hyposmia.

Material And Methods: This was a randomized, double-blind, placebo-controlled study. The criterion for inclusion in the blinded phase was an improvement of at least 2 steps in the butanol odor threshold test following open treatment for 10 days with oral and nasal corticosteroids.