Publications by authors named "East C"

Background: Maternity and neonatal services are rapidly changing in Australia because of evolving needs of the community and patient population. Clinical practice guidelines focused on early interventions and prevention strategies can decrease risk for preventable negative health outcomes in this population. However, despite the existence of several clinical practice guidelines, their translation into practice remains problematic for healthcare services.

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  • Uterine leiomyomas can sometimes lead to serious conditions like deep vein thrombosis (DVT) and pulmonary embolism (PE), even in patients with no known risk factors.
  • A 38-year-old woman experienced leg swelling, pain, and breathing difficulties and was diagnosed with DVT and PE, which were confirmed through imaging.
  • The treatment involved mechanical thrombectomy and hysterectomy, resulting in a full recovery with no recurrence of thromboembolic events after 11 months.
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Background: Obstetric ultrasound is an important tool, aiding in screening, diagnosis, and surveillance throughout pregnancy.

Aims: To explore obstetric doctors', midwives', and sonographers' experiences and views of obstetric ultrasound in Victoria, Australia. To investigate the increasing role of obstetric ultrasound for clinical management, and the adequacy of resources and training for appropriate use of ultrasound in clinical management.

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Hypertension is a leading risk factor for cardiovascular morbidity and mortality. Despite the widespread availability of both pharmacological and lifestyle therapeutic options, blood pressure control rates across the globe are worsening. In fact, only 23% of individuals with high blood pressure in the United States achieve treatment goals.

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Background: The primary cause of maternal and fetal mortality due to hypertensive disorders in pregnancy is delays in accessing healthcare services. These delays are often attributed to insufficient knowledge, attitudes at the time of diagnosis, and a lack of awareness regarding the condition, including its critical warning signs and symptoms.

Aim: To evaluate pregnant women's initial knowledge and attitudes upon receiving their first diagnosis of hypertensive disorders of pregnancy.

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  • The study examined the impact of two medications, sacubitril/valsartan and ramipril, on short-term kidney function changes in patients experiencing acute myocardial infarction (MI), focusing on serum creatinine levels.
  • In a trial with 5,661 patients, it was found that those taking sacubitril/valsartan had a slightly higher likelihood of experiencing initial increases in serum creatinine compared to those taking ramipril.
  • However, acute changes in creatinine levels from either medication did not correlate with worse long-term cardiovascular outcomes or significant changes in kidney function, suggesting the initial increases might not indicate long-term risks.
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Background: It is common for women to explore and plan strategies to cope during labour. These strategies are usually focused on pain control and described as either pharmacological or non-pharmacological. As labour is an individual experience, each woman should be enabled to choose strategies that best suit them, and that reflect what they feel influences their sense of capacity to cope.

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Cyclin dependent kinase 7 (CDK7) is an important therapeutic kinase best known for its dual role in cell cycle regulation and gene transcription. Here, we describe the application of protein engineering to generate constructs leading to high resolution crystal structures of human CDK7 in both active and inactive conformations. The active state of the kinase was crystallized by incorporation of an additional surface residue mutation (W132R) onto the double phosphomimetic mutant background (S164D and T170E) that yielded the inactive kinase structure.

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  • Study Purpose
  • : The research assessed the effectiveness of an "inclisiran first" strategy for patients with atherosclerotic cardiovascular disease who don't reach LDL-C goals, comparing this approach with usual care that only involves statins.
  • Key Findings
  • : 450 patients were randomized, showing that the "inclisiran first" approach resulted in a 60% reduction in LDL-C, compared to just 7% in usual care. It also helped a higher percentage of patients reach LDL-C targets (<70 mg/dL: 81.8% vs 22.2%).
  • Safety and Tolerability
  • : While the "inclisiran first" strategy did not lead to increased serious
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Problem: Physiological birth was defined by the World Health Organization in 1997, however, clinical practices in childbirth have changed considerably since this time.

Background: Ambiguous terms in healthcare such as 'physiological birth' may cause confusion amongst care providers and consumers.

Aim: To identify what is known about physiological birth, and how perceptions of physiological birth manifest in current literature.

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  • Alternative irrigation waters can contain harmful bacterial foodborne pathogens that may contaminate fruits and vegetables, making detection crucial for food safety.
  • A study compared qPCR (real-time PCR) with traditional culture methods for identifying these pathogens, examining factors like water type, season, and sample volume over two years across multiple sites.
  • The findings revealed that qPCR detection had reasonable predictive values, with better agreement observed in spring and summer, particularly in reclaimed and pond water compared to river water, indicating water type influences detection accuracy.
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Background: Across the care economy there are major shortages in the health and care workforce, as well as high rates of attrition and ill-defined career pathways. The aim of this study was to evaluate current evidence regarding methods to improve care worker recruitment, retention, safety, and education, for the professional care workforce.

Methods: A rapid review of comparative interventions designed to recruit, retain, educate and care for the professional workforce in the following sectors: disability, aged care, health, mental health, family and youth services, and early childhood education and care was conducted.

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Background: Birth is a significant event in women's lives. As Mansfield notes (2008) many women aim for a birth that avoids pharmacological pain relief because they are advised it is better for them and their baby. For women having their first baby, this may not be realistic as 3/4 of primiparous women in Australia will use pharmacological pain relief.

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  • Renal denervation (RDN) is a procedure that aims to lower blood pressure (BP) in patients with uncontrolled hypertension, even when they are taking antihypertensive medications.
  • The SPYRAL HTN-ON MED trial was conducted to evaluate the safety and effectiveness of RDN compared to a sham procedure, involving 206 patients in the RDN group and 131 in the control group.
  • Results showed no significant BP difference between the two groups on the primary endpoint, but RDN did lead to lower office BP readings and favorable outcomes in several secondary analyses, with a minimal safety profile.
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Aim: To explore whether sleep deprivation contributes to medication errors in registered nurses (RNs).

Background: Sleep deprivation is a potential issue for RNs, particularly those who work shifts. Sleep deprivation has been found to have a negative impact on numerous cognitive processes.

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Background: Perinatal mental health disorders affect up to 20% of all women. Women of refugee background are likely to be at increased risk, yet little research has explored this. This study aimed to assess if women of refugee background are more likely to screen risk positive for depression and anxiety than non-refugee women, using the Edinburgh Postnatal Depression Scale (EPDS); and if screening in pregnancy using the EPDS enables better detection of depression and anxiety symptoms in women of refugee background than routine care.

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Developing effective and sensitive detection methods for antimicrobial resistant Salmonella enterica from surface water is a goal of the National Antimicrobial Resistance Monitoring System (NARMS). There are no specified methods for recovery of S. enterica in surface waters in the U.

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Background Studies demonstrated sex differences in outcomes following acute myocardial infarction, with women more likely to develop heart failure (HF). Sacubitril/valsartan has been shown to reduce cardiovascular death and HF hospitalizations in patients with HF with reduced ejection fraction. Methods and Results A total of 5661 patients (1363 women [24%]) with acute myocardial infarction complicated by reduced left ventricular ejection fraction (≤40%), pulmonary congestion, or both and ≥1 of 8 risk-augmenting factors were randomized to receive sacubitril/valsartan or ramipril.

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Growing evidence demonstrates the suitability of renal denervation in a broad population of patients; however, questions remain over its suitability and practical implementation. Given the rapidity of emerging data, this has been a challenging field for potential adopters to navigate. The purpose of this article is twofold: to provide navigation through emerging clinical data and evolving guidance; and to provide physicians with practical, evidence-based advice for identifying eligible patients and providing appropriate management in the pre- and postintervention settings.

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Background: Substantial evidence indicates that maternal depression during pregnancy (i.e., antenatal depression) is associated not only with maternal wellbeing but also with child emotional and behavioural development.

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We examine multi-generational impacts of positive in utero health interventions using a new research design that exploits sharp increases in prenatal Medicaid eligibility that occurred in some states. Our analyses are based on U.S.

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There is a need to ensure that healthcare organisations enable their workforces to use digital methods in service delivery. This study aimed to evaluate the current level of digital understanding and ability in nursing, midwifery, and allied health workforces and identify some of the training requirements to improve digital literacy in these health professionals. Representatives from eight healthcare organizations in Victoria, Australia participated in focus groups.

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Background: Delayed reporting of decreased fetal movements (DFM) could represent a missed opportunity to prevent stillbirth. Mobile phone applications (apps) have the potential to improve maternal awareness and reporting of DFM and contribute to stillbirth prevention.

Aims: To evaluate the effectiveness of the My Baby's Movements (MBM) app on late-gestation stillbirth rates.

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