A randomized controlled trial on oblique incisions for ACL reconstruction: Minimizing sensory deficit without compromising outcome.

Aim: This randomized controlled trial aimed to evaluate the impact of different incision types (oblique, vertical, and horizontal) for hamstring graft harvest on sensory disturbances and functional outcomes after anterior cruciate ligament (ACL) reconstruction.

Methods: A total of 118 patients were randomized into three groups: oblique incision (n = 40), vertical incision (n = 40), and horizontal incision (n = 38). Sensory deficits were assessed using Von Frey Filaments at three weeks, three months, and six months postoperatively.

Homozygous truncating variant in causes a novel congenital disorder of glycosylation with neurological involvement.

Background: Enzymes of the Golgi implicated in N-glycan processing are critical for brain development, and defects in many are defined as congenital disorders of glycosylation (CDG). Involvement of the Golgi mannosidase, MAN2A2 has not been identified previously as causing glycosylation defects.

Methods: Exome sequencing of affected individuals was performed with Sanger sequencing of the transcript to confirm the variant.