Publications by authors named "Earl Neel"
Article Synopsis
- Cytochrome c (Cc) experienced rapid evolution from early anthropoid primates to modern humans, showcasing 11 amino acid changes, with five near its binding site to cytochrome c oxidase (CcO).
- The study found that specific mutations in horse and human cytochrome c significantly impacted the dissociation constant (K), particularly at residue 50, where changes led to a notable decrease in binding affinity in horse mutants and an increase in human mutants.
- Phosphomimetic mutants of human Cc suggested that phosphorylation at certain residues enhances the dissociation rate and alters the formation rate of the Cc:CcO complex, emphasizing its regulatory role in mitochondrial function.
