The Tungsten-Promoted Synthesis of Piperidyl-Modified -Methylphenidate Derivatives.

Due to its efficacy as a dopamine receptor agonist, methylphenidate (MPH) is of interest as a potential therapeutic for cocaine addiction. While numerous derivatives of MPH have been investigated for their potential medicinal value, functionalization of the piperidine ring has not been explored. The pyridine borane ligand in WTp(NO)(PMe)(η-pyBH) is dearomatized by the metal and can be elaborated to the analogous η-mesylpyridinium complex.