Publications by authors named "Eamonn R Heney"
Article Synopsis
- Short-chain fatty acids (SCFAs), which have an anti-inflammatory effect, are reduced in multiple sclerosis (MS), with unclear reasons for their depletion in the gut microbiome.* -
- In a study using a model for MS, it was found that certain gut bacteria can worsen symptoms by depleting SCFA-producing microbes and that increased dietary fiber can help counteract this effect.* -
- This research suggests that managing SCFA levels in MS patients may need a combination of dietary changes and adjustments to the gut microbiome to improve health outcomes.*
Background: Dysregulation of gut microbiota-associated tryptophan metabolism has been observed in patients with multiple sclerosis. However, defining direct mechanistic links between this apparent metabolic rewiring and individual constituents of the gut microbiota remains challenging. We and others have previously shown that colonization with the gut commensal and putative probiotic species, Lactobacillus reuteri, unexpectedly enhances host susceptibility to experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis.
View Article and Find Full Text PDF