Publications by authors named "Eamonn O'Donoghue"

Background: Solar maculopathy (SM) is a rare cause of acquired maculopathy related to direct viewing of the sun. Primary symptoms include central scotomata, blurred vision and/or metamorphopsia due to thermal/photochemical damage to foveal photoreceptors.

Methods: Patients were identified from clinic records surrounding a solar eclipse.

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We used a high-resolution confocal scanning laser ophthalmoscope to measure the magnitude of change in retinal arteriolar diameters in response to oxygen breathing in young, healthy nonsmokers and smokers. Image sequences were obtained before and during oxygen breathing. Image sequences were desinusoided, registered, and averaged, before vessel diameters were measured using a sliding linear regression filter.

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A young woman presented with a 2-day history of bilateral central scotoma and metamorphopsia following an episode of direct sun-gazing lasting 1-2 min. On examination, visual acuity was reduced to 6/9 bilaterally. Fundal examination revealed discrete yellow lesions at both maculae consistent with solar burns.

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Purpose: Primary open angle glaucoma is the most prevalent type of glaucoma and the leading cause of irreversible blindness worldwide. The genetic basis is poorly understood. Of 14 loci associated with this disease, only two genes have been identified, accounting for approximately 4% of cases.

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