The macroeconomic effects of lockdown policies.

A tractable incomplete-market model with endogenous unemployment risk, sticky prices, real wage rigidity and a fiscal side is calibrated to Euro Area countries and used to analyze the macroeconomic effects of lockdown policies. Modeling them as a shock to the extensive margin of labor adjustment - a rise in separations - produces large and persistent negative effects on output, unemployment and welfare, raises precautionary savings and lowers inflation, in line with early evidence about inflation dynamics. Modeling lockdowns as a shock to the intensive margin - a fall in labor utilization - produces small and short-lived macroeconomic and welfare effects, and implies a counterfactual rise in inflation.

Taking off into the wind: Unemployment risk and state-Dependent government spending multipliers.

We propose a model with involuntary unemployment, incomplete markets, and nominal rigidity, in which the effects of government spending are state-dependent. An increase in government purchases raises aggregate demand, tightens the labor market and reduces unemployment. This in turn lowers unemployment risk and thus precautionary saving, leading to a larger response of private consumption than in a model with perfect insurance.

Normal and altered masticatory load impact on the range of craniofacial shape variation: An analysis of pre-Hispanic and modern populations of the American Southern Cone.

The reduction of masticatory load intensity resulting from dietary changes in human evolution has been proposed as an important factor that alters craniofacial shape in past and current populations. However, its impact on craniofacial variation and on the perceived differences among populations is unclear. The maxillomandibular relationship, which alters masticatory force direction, is a factor often neglected but it can contribute to variation in craniofacial morphology, particularly among modern/urban populations where the prevalence of dental malocclusions is greater than in prehistoric populations.

Dental malocclusions are not just about small and weak bones: assessing the morphology of the mandible with cross-section analysis and geometric morphometrics.

Objectives: Dental malocclusions in modern populations would be the result of small and weak jaws developing under low masticatory loads. We assess the validity of this by characterising the external and internal morphology of mandibles affected by class II and III malocclusions and comparing them with those from individuals with different masticatory load patterns.

Materials And Methods: CTs from up to 118 individuals exerting intensive, medium and low masticatory loads with harmonic occlusion, and from class II and III individuals, were used to compare their external shape using geometric morphometrics, as well as their internal amount and distribution of cortical bone.

Co-localization and secretion of parathyrin of Stannius corpuscles (immunoreactive parathyroid hormone) and of secretory glycoproteins including secretory protein-I in the European eel (Anguilla anguilla L.).

Until recently, teleosts were considered to be devoid of parathyroids. We showed recently that the corpuscles of Stannius, that structurally have features in common with the parathyroid gland, produce a molecule resembling mammalian parathyroid hormone (PTH). We refer to this molecule as parathyrin of corpuscles of Stannius (PCS).

IgG-subclass expression of anti-DNA and anti-ribonucleoprotein autoantibodies in human malaria.

To understand further the autoimmune phenomena associated with human malaria, we examined the IgG-subclass expression of antibodies to DNA and to ribonucleoproteins (RNP) in the serum of 99 patients with acute malaria. Of the sera, 22% were positive for single-stranded DNA (ssDNA), 18% for double stranded DNA (dsDNA) and 32% for RNP. Using a set of human IgG-subclass-specific murine monoclonal antibodies, we found that autoantibodies to dsDNA were predominantly expressed in the IgG1 subclass.

Suppression of murine lupus autoantibodies to DNA by administration of muramyl dipeptide and syngeneic anti-DNA IgG.

We evaluated the effect of repeated subcutaneous administration of syngeneic anti-DNA IgG and muramyl dipeptide, a synthetic immunoadjuvant, to 6-mo-old (NZB X NZW)F1 female mice. This treatment had profound effects on both idiotype expression and anti-DNA antibody levels of morbid mice. It was also associated with appearance of anti-idiotypic antibodies specific for the injected antibody.

[Value of the detection of antithyroid antibodies in thyroid pathology].

Antithyroid microsomal hemagglutination antibody (MCHA) and antithyroglobulin hemagglutination antibody (TGHA) were measured in 629 patients with thyroid disease and 100 controls. Thyroid antibodies were present in 4% of control patients, only in women and at low titer. Thyroid antibodies prevalence was 97% in autoimmune thyroiditis (MCHA: 93%; TGHA: 53%), was 55% in Graves disease before treatment (MCHA: 46%; TGHA: 33%) and 90% in the first year following 131I therapy.

Idiotypic interrelationship among human myeloma proteins with distinct antibody-binding specificities.

There have been several reports of human myeloma proteins exhibiting autoantibody activity. Such immunoglobulins represent therefore an appropriate system for investigating idiotypic diversity of human autoantibodies. Using this approach, we confirmed the marked idiotypic restriction of polyclonal anti-DNA autoantibodies and we showed that immunoglobulins without known binding affinity may express autoantibody-related idiotopes.

Idiotypy of anti-Rh antibodies.

Anti-id sera to Rh antibodies were produced by injecting rabbits with purified Rh antibodies. These sera were shown to agglutinate O Rh+ RBC coated by the immunizing antibody and--in some cases--by other anti-D antibodies. Id and cross-reactive id were shown to be located in the antigen-binding and in the non-antigen binding regions of Rh antibodies.

Anti-DNA autoantibody activity and idiotypic relationships of human monoclonal proteins.

Previous studies showed that polyclonal anti-DNA antibodies from patients with systemic lupus erythematosus (SLE) share cross-reactive idiotypes (CRI). In this report, we used human myeloma proteins (HMP), isolated from the serum of patients with multiple myeloma or Waldenström macroglobulinemia, as probes to further explore this idiotypic cross-reactivity. Fourty-four HMP were tested for DNA-binding capacity and for expression of CRI associated with lupus anti-DNA antibodies.

[Immunological study of a hemophiliac treated according to the Bonn protocol for 2 1/2 years].

A major haemophiliac A, 27 years old, has been treated during 30 months, with high dosage of imported Factor VIII, in order to reduce the titer of a F VIII antibody. A good clinical result has been obtained. No sign of immunodeficiency has been observed.

Regulation by muramyl dipeptide (MDP) of the lymphoproliferative responses and polyclonal activation of human peripheral blood mononuclear cells.

The ability of muramyl dipeptide (MDP), its adjuvant inactive stereoisomer, MDP(D-D), and the non-pyrogenic, adjuvant active analogue, MDP-butyl ester (MDP-BE), to induce in vitro proliferation and/or polyclonal activation (PA) of peripheral blood mononuclear cells (PBMNC) from normal volunteers, was studied. MDP, as well as its two analogues, were incapable of inducing 3H-thymidine uptake or immunoglobulin synthesis in PBMNC cultures from the majority of the individuals tested. However, these muramyl peptides were capable of regulating the in vitro proliferative responses of some individuals to concanavalin A and to soluble antigens of Candida albicans.

A human monoclonal IgG1 with anti-idiotypic activity against anti-human thyroglobulin autoantibody.

Sixty-one human myeloma proteins (HMP) from patients with multiple myeloma and Waldenström macroglobulinemia were tested for anti-idiotypic (Id) activity against autoantibodies to double-stranded DNA, small nuclear ribonucleoproteins, and human thyroglobulin (HTg), by competitive radioimmunoassays and enzyme immunoassays. An IgG1, lambda HMP from patient BEN with anti-Id activity against antibodies to HTg is reported. IgG1 BEN was not directed toward human Fc fragments and its activity was not related to allotypic determinants.

[Heterohemagglutinins in human malaria: immunopathologic implications].

The prevalence of heterohemagglutinins was investigated both in sera of Africans from a malaria endemic area of Upper Volta and in sera of individuals with acute malaria from a parisian hospital. Hemagglutinins against horse, sheep, goat, chicken, pigeon and duck red blood cells were tested. The results showing an increased frequency of high titres of these hemagglutinins are discussed in terms of the mechanisms leading to autoantibody hyperproduction in malaria.

Antibodies to heterogeneous nuclear ribonucleoproteins in sera from patients with rheumatic autoimmune diseases.

Ribonucleoprotein (RNP) particles sedimenting at 40 S in sucrose gradients were prepared from calf thymus nuclei. They were identified as heterogeneous nuclear RNP (hnRNP) on the basis of size, electron microscopic examination, buoyant density, and protein electrophoretic patterns. Sera from patients with systemic lupus erythematosus, rheumatoid arthritis, and mixed connective tissue disease were found to interact with hnRNP by counter-immunoelectrophoresis and enzyme-linked immunosorbent assay (ELISA).

IgG subclass distribution of autoantibodies to DNA and to nuclear ribonucleoproteins in autoimmune diseases.

Fifty-seven serum samples positive for antibodies to double-stranded DNA (dsDNA), single-stranded DNA (ssDNA) or small nuclear ribonucleoproteins (snRNP) selected from patients with systemic lupus erythematosus and mixed connective tissue disease, were examined for the IgG subclass distribution of these autoantibodies. It was shown that antibodies to dsDNA were relatively restricted to IgG1 and IgG3 subclasses whilst antibodies to ssDNA were equally distributed throughout the four subclasses. Antibodies to snRNP were essentially restricted to the IgG2 isotype.

Evaluation of auto-antibodies in chronic mucocutaneous candidiasis without endocrinopathy.

Six patients with chronic mucocutaneous candidiasis (CMCC) were investigated for the presence of auto-antibodies during the course of the infection. Sera were tested for antibodies to native DNA (dsDNA) and denatured DNA (ssDNA), mitochondrial and microsomal antigens, smooth muscle, gastric parietal cells, basal membrane and skin intercellular substance, parathyroid glands, thyroglobulin and microsomal antigen, immunoglobulins and for anti-nuclear antibodies. Auto-antibodies were detected by radioimmunoassay, immunofluorescence, hemagglutination and other routine methods.

Idiotype restriction in human autoantibodies to DNA in systemic lupus erythematosus.

Antibodies (Ab) to double stranded DNA (dsDNA) were immunoaffinity-purified from the serum of patient TOF with active systemic lupus erythematosus (SLE). Anti-idiotypic Ab to TOF anti-DNA were raised in rabbit. They were shown to recognize TOF F(ab')2 fragments, but they did not interact with human Ab of other specificities or with TOF IgG depleted of anti-DNA activity.

[Ciliary activity of cells of the fallopian tubes (apropos of the sequellae of salpingitis)].

A study was made of ciliary movement in tubal epithelium using microphotooscillography on the tubes of 91 patients who were operated on for tubal, ovarian or uterine pathology. Three groups were classified: 31 with healthy tubes, 47 with tubes that showed the consequences of salpingitis. These patients had been operated on for sterility after much treatment with antibiotics and corticoids.

Immunocytochemical detection in eel corpuscles of Stannius of a mammalian parathyroid-like hormone.

Stannius corpuscles of the eel synthesize and secrete a mammalian parathyroid-like hormone called parathyrin of CS (PCS). PCS has been localized in the cytoplasm of all cells in the corpuscles, detection being by indirect immunofluorescence with an antiserum anti-1-84 bovine hormone (PTH). The specificity of the reaction was demonstrated by inhibition of the fluorescent staining with 1-84 bovine PTH and the active fragment 1-34 of human PTH.