Multicenter phase II study to evaluate a 28-day regimen of oral fluorouracil plus eniluracil in the treatment of patients with previously untreated metastatic colorectal cancer.

Purpose: To determine the efficacy of fluorouracil (5-FU) plus eniluracil when administered to patients with previously untreated metastatic colorectal cancer.

Patients And Methods: In this single-arm phase II study, patients with previously untreated metastatic colorectal cancer received oral eniluracil plus 5-FU (10:1 dose ratio), at 5-FU doses of 1.00 mg/m(2) or 1.

A Comparison of Oral Ondansetron and Intravenous Granisetron for the Prevention of Nausea and Emesis Associated with Cisplatin-Based Chemotherapy.

PURPOSE: To compare the efficacy and safety of oral ondansetron with i.v. granisetron each given as a single dose prior to administration of highly emetogenic cisplatin chemotherapy.

Analysis of human urine for mutagens associated with carcinoma of the bilharzial bladder by the Ames Salmonella plate assay.

The Ames Salmonella plate assay was employed to test urine samples from bladder cancer patients and controls living in Egypt for the presence of chemical mutagens. Urine from five groups of Egyptian adults were tested, including individuals with (1) neither bilharziasis nor bladder cancer, (2) urinary bilharziasis and normal urinary cytology, (3) urinary bilharziasis and atypical urinary cytology, (4) carcinoma of the bilharzial bladder, and (5) bladder cancer without bilharziasis. Plates treated with histidine dependent bacteria, S-9 mix, beta-glucuronidases and 0.