Implantable Neuromodulation for Neurogenic Lower Urinary Tract Dysfunction: A Single-Institution Retrospective Study.

Purpose: Neurogenic lower urinary tract dysfunction (NLUTD) is highly prevalent among patients with neurologic disorders. Some studies have demonstrated that implantable neuromodulation can improve symptoms of NLUTD. We seek to describe our experience with sacral and pudendal neuromodulation in patients with NLUTD.

Seasonal variation in cuckoldry rates in the socially monogamous cichlid fish .

Unlabelled: Mating patterns in animal populations can respond to environmental conditions and consequently vary across time. To examine this variation in nature, studies must include temporal replicates from the same population. Here, we report temporal variation in genetic parentage in the socially monogamous cichlid from Lake Tanganyika, using samples of broods and their brood-tending parents that were collected across five field trips from the same study population.

The Crystal Structure of Mouse Ces2c, a Potential Ortholog of Human CES2, Shows Structural Similarities in Substrate Regulation and Product Release to Human CES1.

Members of the carboxylesterase 2 (Ces2/CES2) family have been studied intensively with respect to their hydrolytic function on (pro)drugs, whereas their physiological role in lipid and energy metabolism has been realized only within the last few years. Humans have one CES2 gene which is highly expressed in liver, intestine, and kidney. Interestingly, eight homologous Ces2 (Ces2a to Ces2h) genes exist in mice and the individual roles of the corresponding proteins are incompletely understood.

Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease.

Carboxylesterase 2 (CES2/Ces2) proteins exert established roles in (pro)drug metabolism. Recently, human and murine CES2/Ces2c have been discovered as triglyceride (TG) hydrolases implicated in the development of obesity and fatty liver disease. The murine Ces2 family consists of seven homologous genes as opposed to a single CES2 gene in humans.

Croup, a disorder of the anal phase of development. A contribution to our understanding of the psychosexual development of the larynx.

A brief history of croup is presented. The forms of croup under examination are defined with emotional factors at one end of a continuum and viral and traumatic factors at the other. The complexity of the disorder and its peculiar clinical characteristics are explained.

Antagonistic effects of sulfide and butyrate on proliferation of colonic mucosa: a potential role for these agents in the pathogenesis of ulcerative colitis.

It has been shown that feces of patients with ulcerative colitis uniformly contain sulfate reducing bacteria. Sulfide produced by these bacteria interferes with butyrate-dependent energy metabolism of cultured colonocytes and may be involved in the pathogenesis of ulcerative colitis. Mucosal biopsies from the sigmoid rectum of 10 patients (no caner, polyps, inflammatory bowel disease) were incubated with either NaCl, sodium hydrogen sulfide (1 mmol/L), a combination of both sodium hydrogen sulfide and butyrate (10 mmol/L), or butyrate.

Chernobyl fallout on Alpine glaciers.

Measurements of the gross beta activity of snow samples from four Alpine glaciers contaminated by radioactive fallout from the Chernobyl nuclear accident and a gamma-spectrum analysis of selected samples are reported. The results are discussed with respect to possible risks to the population from using meltwater from these glaciers as drinking water.

Returning the not guilty by reason of insanity to the community: a new scale to determine readiness.

The very difficult and very important decision on the readiness of an insanity acquittee for community treatment is often based on informal, invalidated criteria. A more standardized approach is needed. The bases for decisions can then be more clearly articulated and the adequacy of recommendations evaluated.

Displacement of Chernobyl fallout in snow layers of temperate Alpine glaciers.

Measurements of the gross-beta-activity and a gamma-spectrum analysis of radioactive fallout from Chernobyl distributed in vertical snow profiles on an Alpine glacier were carried out. Samples were collected in summer 1986 and in summer 1987. A displacement of isotopes to depths of approximately 6 m was observed.

Community mental health and the elderly: service and training approaches.

There is a growing gap between needed and available mental health services for older adults. This article discusses the training needs, personnel shortages, and lack of effective service programs and proposes some strategies for dealing with the problems. There is a lack of adequate methods for identifying and referring frail elderly persons in need of mental health services.

Tissue distribution of [14C]ethambutol in mice.

Fifteen male mice were given oral doses of 32 mg [14C]ethambutol/kg in a study of the tissue distribution of the drug. Animals were killed 1, 2, 4, 7, and 24 h after dosage and radioactivity in various tissues was measured. Peak concentrations were seen at 2 h after dosage.

Metabolic and pharmacokinetic studies with fenbufen in man.

Single oral doses of 600 mg of 14C-labelled gamma-oxo(1,1'-biphenyl)-4-butanoic acid (fenbufen) were administered to three male volunteers. Additional male and female subjects received single (500-700 mg) or multiple (300-400 mg b.i.

Disposition and metabolism of fenbufen in several laboratory animals.

Absorption, distribution, metabolism and excretion studies with gamma-oxo-(1,1'-biphenyl)-4-butanoic acid (fenbufen) have been conducted in several laboratory animal species. Single oral doses of 14C-fenbufen were administered to rats, guinea pigs, rabbits and dogs (10, 40 and 100 mg/kg) and to mice and monkeys (40 and 100 mg/kg); rats, rabbits and dogs received an i.v.

Cyanogenic Glandular Apparatus of a Millipede.

The cyanogenic secretion of the polydesmoid millipede Apheloria corrugata (Wood) is discharged from paired, serially arranged glands, each consisting of two compartments. In one compartment is stored an undissociated cyanogenic compound, and in the other, a chemical factor that triggers cyanogenesis. The gland is constructed in such a way that the contents of the two compartments are mixed, and cyanogenesis is initiated, at the very instant of discharge.