Validation of the Parkinson's Disease Caregiver Burden Questionnaire in Progressive Supranuclear Palsy.

Progressive supranuclear palsy (PSP) is an atypical Parkinson syndrome with axial akinetic-rigid symptoms, early postural instability, and ocular motor impairments. Patients experience a rapid loss of autonomy and care dependency; thus, caregivers must assist in the activities of daily living early in the course of the disease. Caregiver burden is an extremely important factor in disease management.

Pyridine Nucleotide-Linked Lactate Dehydrogenase of Tetrahymena: Evidence for D- and L-Enzymes in the Mitochondria.

An NAD-linked lactate dehydrogenase (LDH) in a crude mitochondrial fraction obtained from Tetrahymena homogenates was previously reported by this laboratory. This fraction contains the NADH and succinate oxidase system as well as the mitochondrial cytochromes and carries out oxidative phosphorylation. The preparation catalyzes the oxidation of D- and L-lactate linked only to certain analogs of NAD; it has not been possible to demonstrate NAD-dependent D- or L-lactate oxidation nor is there any evidence that either of these enzymes is a flavoprotein as indicated by their inability to reduce directly certain artificial electron acceptors.

[Significance of postrotatorius II within the scope of the rotatory test].

In 68 patients suffering from acute unilateral vestibular disorders 168 electronystagmograms could be analysed paying special attention to the nystagmographic reactions in the second postrotatory period. When the postrotatorius II was directed to the affected side (in 25% of our cases) this was an indication for an advanced extent of central compensation in the electronystagmogram. There was a good correlation between the postrotatorius II and the other nystagmographic reactions in the per- and postrotatory periods.

[Value of the rotation test in acute unilateral vestibular disorders].

The electronystagmographically recorded response of the spontaneous nystagmus and of the per- and postrotatory nystagmus were examined in 70 patients suffering from acute unilateral vestibular disorders. Within a short time the SPN declined logarithmically compared to the reduction of the perrotatory directional preponderance. But the postrotatory nystagmus levels changed only a little in the course of time.

Intracellular localization of enzymes in spleen. II. Some properties and the distribution of ribonuclease in rat spleen.

Some properties of rat spleen ribonuclease have been studied, and the intracellular distribution of the enzyme and ribonucleic acid have been presented. Spleen ribonuclease exhibits maximal activity at pH 5.8, and although there is some evidence for the presence of an enzyme with an optimum at pH 7.