Association of Supine Hypertension Versus Standing Hypotension With Adverse Events Among Middle-Aged Adults.

Background: Management of orthostatic hypotension (OH) prioritizes prevention of standing hypotension, sometimes at the expense of supine hypertension. It is unclear whether supine hypertension is associated with adverse outcomes relative to standing hypotension.

Objectives: To compare the long-term clinical consequences of supine hypertension and standing hypotension among middle-aged adults with and without OH.

Dietary Sodium Reduction Is Best for Reducing Blood Pressure: Controversies in Hypertension.

The global burden of cardiovascular disease (CVD) continues to grow, as does the incidence of hypertension, one of the most important modifiable risk factors of CVD. Non-pharmacologic, population level interventions are critically needed to halt the hypertension pandemic, but there is an ongoing debate as to whether public policy efforts should focus more on dietary sodium reduction or increasing potassium. In this commentary, we summarize arguments in favor of policy geared towards reduced sodium intake.

Standing Blood Pressure and Risk of Falls, Syncope, Coronary Heart Disease, and Mortality.

Background: ACC/AHA guidelines caution against the use of antihypertensive therapy in the setting of low standing systolic BP (SBP) < 110 mm Hg due to unclear benefits.

Methods: The Atherosclerosis Risk in Communities (ARIC) Study measured supine and standing SBP in adults aged 45-64 years between 1987 and 1989. We used Cox regression to evaluate the associations of low standing SBP (<110 mm Hg) with risk of falls, syncope, coronary heart disease (CHD), and mortality through December 31, 2019.

Less sodium, more potassium, or both: population-wide strategies to prevent hypertension.

Hypertension is among the most prevalent medical conditions globally and a major contributor to chronic kidney disease, cardiovascular disease, and death. Prevention through nonpharmacological, population-level interventions is critically needed to halt this worldwide epidemic. However, there are ongoing disagreements as to where public policy efforts should focus.

HPV vaccination and HPV-related malignancies: impact, strategies and optimizations toward global immunization coverage.

HPV-related diseases represent a major cause of morbidity and mortality, although effective HPV vaccines are available, potentially allowing for the elimination of these malignancies. Historically, most of the available literature has focused on cervical cancer, the fourth commonest cause of cancer-related death worldwide, whose incidence is heterogeneous mirroring the inequitable distribution of facilities for screening and treatment and vaccination programs. A broader vision of HPV vaccination impact is needed to understand the potential effect of a global high immunization coverage on both cervical cancer and other HPV-associated malignancies, in women and men.

Reducing use of triple therapy after percutaneous coronary intervention: Results from a hospital-wide quality improvement initiative.

Background: Trials have shown that for patients on oral anticoagulants (OAC), a short course of dual antiplatelet therapy (DAPT) with OAC reduces post-percutaneous coronary intervention (PCI) bleeding without increasing ischemic events. Adoption of this strategy has been variable. We evaluated the impact of an institutional quality improvement (QI) initiative to reduce the use of triple therapy (TT, OAC + DAPT) and improve discharge communication post-PCI.

Current Unmet Needs in Penile Cancer: The Way Forward?

Objective: In collaboration with the world's largest online penile cancer support group, the authors created a simple, anonymous survey to highlight and discuss some of the current problems experienced globally by men who have been diagnosed and treated for penile cancer over the last 5-10 years.

Data Sources: The world's largest online penile cancer support community group, https://www.facebook.

Plazomicin for the treatment of multidrug-resistant bacteraemia in a patient with underlying chronic kidney disease and acute renal failure requiring renal replacement therapy.

A 75-year-old man presented with shortness of breath and somnolence and was found to have urosepsis. Blood and urine cultures subsequently grew multidrug-resistant (MDR) (Kp) with the New Delhi metallo-β-lactamase gene. The patient was treated successfully with plazomicin and meropenem/vaborbactam combination therapy.

Dietary nitrate supplementation and exercise tolerance in patients with heart failure with reduced ejection fraction.

Endothelial dysfunction and reduced nitric oxide (NO) signaling are key abnormalities leading to skeletal muscle oxygen delivery-utilization mismatch and poor physical capacity in patients with heart failure with reduced ejection fraction (HFrEF). Oral inorganic nitrate supplementation provides an exogenous source of NO that may enhance locomotor muscle function and oxygenation with consequent improvement in exercise tolerance in HFrEF. Thirteen patients (left ventricular ejection fraction ≤40%) were enrolled in a double-blind, randomized crossover study to receive concentrated nitrate-rich (nitrate) or nitrate-depleted (placebo) beetroot juice for 9 days.

A new invasive weed-feeding species of Polypedilum (Pentapedilum) Kieffer from South Africa (Diptera: Chironomidae, Chironominae).

Polypedilum (Pentapedilum) tuburcinatum Andersen et Bello González sp. n. is described and figured as male, female, pupa and larva based on material collected in the Eastern Cape Province in South Africa, imported into quarantine in Ireland and reared in the laboratory.

Measurement of the positive muon lifetime and determination of the Fermi constant to part-per-million precision.

We report a measurement of the positive muon lifetime to a precision of 1.0 ppm; it is the most precise particle lifetime ever measured. The experiment used a time-structured, low-energy muon beam and a segmented plastic scintillator array to record more than 2×10(12) decays.

The nature of telephone nursing interventions in a heart failure clinic setting.

Background: There is a lack of published data about the nature of nursing interventions that are required to provide telephone management for patients with heart failure (HF).

Purpose: The nature of patient issues, telephone nursing interventions, and associated workload at one HF clinic are described in this study.

Methods: Workload was captured using a computerized workload measurement tool.

Improved measurement of the positive-muon lifetime and determination of the Fermi constant.

The mean life of the positive muon has been measured to a precision of 11 ppm using a low-energy, pulsed muon beam stopped in a ferromagnetic target, which was surrounded by a scintillator detector array. The result, tau(micro)=2.197 013(24) micros, is in excellent agreement with the previous world average.

The role and scope of practice of nurses working in Canadian heart failure clinics.

Background: Nurses play an integral role in providing care in heart failure (HF) clinics and disease management programs that lead to improved outcomes for HF patients.

Objectives: This pilot study explored how closely nurses in Canadian HF clinics follow consensus guideline recommendations and nursing interventions from published studies.

Methods: A total of 27 nurses from HF clinics across Canada completed a questionnaire about their role and scope of practice.

A high voltage RF oscillator for driving multipole ion guides.

A high voltage RF oscillator circuit has been designed and constructed for driving multipole ion guides. The circuit is tunable from 500 kHz to 1.5 MHz by changing a capacitor and provides 0-1000 V(p-p) that is controlled by a 0-10 V input using a negative feedback circuit.