Publications by authors named "E-Nuo Dai"
Article Synopsis
- Osteoarthritis (OA) involves cartilage degradation and osteophyte formation, and this study specifically investigates the role of the microRNA miR-1207-5p in OA development.
- Analysis revealed that miR-1207-5p levels decrease while CX3CR1 levels increase in OA cartilage, and boosting miR-1207-5p helps reduce cell damage and ECM degradation caused by inflammation.
- The findings suggest that miR-1207-5p has protective effects against OA by targeting CX3CR1, potentially offering new insights for OA treatment strategies.
Objective: This study aims to explore the role of MARK2 in chemotherapeutic resistance and potential mechanism within cisplatin resistance models of CD133 MG-63 and MNNG/HOS cells.
Methods: CD133 and CD133 MG-63 and MNNG/HOS cells were differentiated and obtained by MACS(Magnetic bead sorting). Cell activity was determined by CCK-8 assay.
Osteosarcoma (OS) is the most common primary malignancy of skeleton with higher mortality rates amongst children and young adults worldwide, whereas effective and secure therapies have also been sought by researches with ongoing efforts. The purpose of the present study was to investigate the impact of N'-[(3Z)-1-(1-hexyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene] benzohydrazide (MDA19) on OS and explore its potential mechanism. Cell Counting Kit-8 (CCK8) and colony formation assay were employed to evaluate the potential effect of MDA19 on U2OS and MG-63 cells proliferation.
View Article and Find Full Text PDFCantharidin (CTD), a component of Mylabris (blister beetle), is a traditional Chinese medicine that exerts an anticancer effect in multiple types of cancer cells. The aim of the present study was to investigate whether CTD exhibited anti-metastatic and inhibitory cell proliferation effects against human non-small cell lung cancer (NSCLC) A549 cells, and the possible underlying mechanism by which this occurs. The results of the present study demonstrated that CTD arrested proliferation, suppressed invasion and migration and induced apoptosis in A549 cells .
View Article and Find Full Text PDFArticle Synopsis
- * The research constructed multiple differential co-expression networks (M-DCNs) to identify 'seed genes,' which served as starting points for discovering candidate modules, leading to the identification of four differential modules (4-DMs) through statistical analysis.
- * A significant 4-DM (module 3) showed dynamic changes across all OS grades and was enriched in pathways related to ubiquitin-mediated proteolysis and ribosomes, highlighting the potential importance of these pathways in oste