Publications by authors named "E von Oort"
Article Synopsis
- The establishment of initiatives centered on the Three Rs (Replacement, Reduction, and Refinement) has been bolstered by the adoption of new protective regulations for animals in scientific research.
- Recent articles have been published to review the growth and current activities of European Three Rs centres and platforms, detailing their financial structures, core functions, and ongoing projects.
- These centres serve as crucial hubs for promoting the Three Rs principles, offering models for sustainability and facilitating information sharing in their countries.
Article Synopsis
- * Numerous Three Rs centres and platforms have been established to create new methods, share knowledge, and implement these principles in policies and education, encouraged by legislation aimed at protecting animals used in research.
- * This article provides an overview of European Three Rs centres, their historical development, and previews subsequent articles discussing their current focuses, tasks, and future plans for enhancing non-animal research methods and practices.
Background: Systematic reviews (SRs) are cornerstones of evidence-based medicine and have contributed significantly to breakthroughs since the 1980's. However, preclinical SRs remain relatively rare despite their many advantages. Since 2011 the Dutch health funding organisation (ZonMw) has run a grant scheme dedicated to promoting the training, coaching and conduct of preclinical SRs.
View Article and Find Full Text PDFImportance: Young mouse plasma restores memory in aged mice, but, to our knowledge, the effects are unknown in patients with Alzheimer disease (AD).
Objective: To assess the safety, tolerability, and feasibility of infusions of young fresh frozen plasma (yFFP) from donors age 18 to 30 years in patients with AD.
Design, Setting, And Participants: The Plasma for Alzheimer Symptom Amelioration (PLASMA) study randomized 9 patients under a double-blind crossover protocol to receive 4 once-weekly infusions of either 1 unit (approximately 250 mL) of yFFP from male donors or 250 mL of saline, followed by a 6-week washout and crossover to 4 once-weekly infusions of an alternate treatment.
A round table discussion was held during the LAVA-ESLAV-ECLAM conference on Reproducibility of Animal Studies on the 25th of September 2017 in Edinburgh. The aim of the round table was to discuss how to enhance the rate at which the quality of reporting animal research can be improved. This signed statement acknowledges the efforts that participant organizations have made towards improving the reporting of animal studies and confirms an ongoing commitment to drive further improvements, calling upon both academics and laboratory animal veterinarians to help make this cultural change.
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