Publications by authors named "E van den Oord"
Background: Alcohol use disorder (AUD) has a profound public health impact. However, understanding of the molecular mechanisms that underlie the development and progression of AUD remains limited. Here, we investigated AUD-associated DNA methylation changes within and across 2 addiction-relevant brain regions, the nucleus accumbens and dorsolateral prefrontal cortex.
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- The study investigates the relationship between health risks and epigenetic aging using data from individuals followed from age 9 to 35, focusing on psychiatric, lifestyle, and adversity factors.
- Concurrent analyses found a significant link between BMI and epigenetic aging at the individual level, but not at the timepoint level; lagged analyses revealed that depressive symptoms during adolescence predict accelerated epigenetic aging in adulthood.
- The findings suggest that while immediate changes in health risks do not accelerate biological aging, childhood experiences—especially depressive symptoms—can have long-term effects on epigenetic aging, highlighting the need for further research on these relationships over time.
Article Synopsis
- Scientists found that anesthesia during childbirth can change the DNA tags in newborn babies' blood, which is called the methylome.
- They noticed that different types of anesthesia, like laughing gas and pudendal block, affected different blood cells in babies.
- This study is important because it helps us understand how pain relief given to moms during delivery might have an impact on their newborns' biology.
Drug labeling and instructions provide essential information for patients regarding the usage of drugs. Instructions for the dosage of drug usage are critical for the effectiveness of the drug and the safety of patients. The dosage of many drugs varies depending on the patient's age.
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- - DNA methylation (DNAm) is a way scientists measure aging in living things, and it usually decreases as we get older but sometimes it can increase too.
- - Researchers found that certain DNA areas that gain methylation with age are connected to a special group of proteins called PRC2, which helps control gene activity.
- - They suggest a new measurement called the "PRC2-AgeIndex" to help track how fast our cells are aging, which could help scientists understand how different ways to stay young might work.