Publications by authors named "E van den Bogaert"
Purpose: This study aims to accurately predict the effects of hormonal therapy on prostate cancer (PC) lesions by integrating multi-modality magnetic resonance imaging (MRI) and the clinical marker prostate-specific antigen (PSA). It addresses the limitations of Convolutional Neural Networks (CNNs) in capturing long-range spatial relations and the Vision Transformer (ViT)'s deficiency in localization information due to consecutive downsampling. The research question focuses on improving PC response prediction accuracy by combining both approaches.
View Article and Find Full Text PDF8q21.11 microdeletions encompassing the gene encoding transcription factor ZFHX4, have previously been associated by us with a syndromic form of intellectual disability, hypotonia, decreased balance and hearing loss. Here, we report on 57 individuals, 52 probands and 5 affected family members, with protein truncating variants (n=36), (micro)deletions (n=20) or an inversion (n=1) affecting with variable developmental delay and intellectual disability, distinctive facial characteristics, morphological abnormalities of the central nervous system, behavioral alterations, short stature, hypotonia, and occasionally cleft palate and anterior segment dysgenesis.
View Article and Find Full Text PDFAims: The oropharyngeal dysphagia (OD) poses substantial health risks and affects quality of life. Patient-reported outcome measures (PROMs) are gaining prominence for their crucial role in early detection and adapting rehabilitation and management decisions. This highlights the need for culturally pertinent versions in different languages, especially when addressing conditions like OD.
View Article and Find Full Text PDFArticle Synopsis
- Neurodevelopmental disorders (NDDs) stem from brain development issues, and research identifies loss-of-function (LoF) variations in the ZFHX3 gene as a cause of syndromic intellectual disability (ID).
- A study of 42 individuals shows that variants in ZFHX3 lead to diverse symptoms like intellectual disability, autism spectrum disorder, distinct facial features, and developmental delays.
- ZFHX3 plays a vital role in brain development, influences gene expression related to the nervous system, and has specific DNA methylation patterns linked to its function.
Improving the modelling of a multi-leaf collimator with tilted leaf sides used in radiotherapy.
Phys Imaging Radiat Oncol
January 2024
Background And Purpose: Multi-leaf collimators (MLCs) with tilted leaf sides have a complex transmission behaviour that is not easily matched by radiotherapy treatment planning systems (TPSs). We sought to develop an MLC model that can accurately match test fields and clinically relevant plans at different centres.
Materials And Methods: Two new MLC models were developed and evaluated within a research version of a commercial TPS.