[Interrelation of animal genotype and viral strain characteristics to the course of experimental tick-borne encephalitis].

Differences in the susceptibility to a single subcutaneous inoculation of tick-borne encephalitis (TBE) virus, features of immune response and development of resistance were studied in animals of one species but 2 genotypes (mouse lines CBA and C57BL). In the formation of resistance, the determining factors include the degree of susceptibility, specific sensitization of the animal to the definite antigen, and the level of specific microglobulins. No resistance is formed in C57BL mice highly sensitive to TBE virus antigen.

[Features of immunogenesis in simians infected with attenuated strains of tick-borne encephalitis and Langat virus].

Certain parameters of humoral and cellular immunity induced by attenuated tick-borne encephalitis (TBE) and Langat virus strains were studied in monkeys. The immunogenic activity of the strains inoculated subcutaneously and intracerebrally was manifested by two processes: synthesis of specific antibody and cellular immune response. The highest titers of humoral immunity in N, HI, and CF tests were observed to homologous viruses.

[Functional activity of the macrophage elements of animal peritoneal exudate in the process of infection by tick-borne encephalitis complex viruses].

Investigations of the functional activity values of macrophages showed that free peritoneal macrophages of random-bred mice and guinea pigs participated in primary immune response to a single subcutaneous inoculation of the Pan strain of tick-borne encephalitiss virus. TR-21 strain of Langat virus, and the 237 strain, an experimentally attenuated variant of the latter. When the mice developed an acute infection, functional changes of macrophages were characterized by increased phagocytic activity towards infected cells.

[Comparative study of B-lymphocyte activity in the spleen of mice infected with viruses of the tick-borne encephalitis complex].

Most arbovirus infections are characterized by multiplication of the causative agent in tissues of the reticuloendothelial system. In this study, the effect of some viruses of the tick-borne encephalitis complex on the reaction of B-cells of mouse spleens was investigated by the hemolysin-producing activity (number of plaque-forming cells). To equal small doses of a highly virulent (Pan), naturally attenuated (Tp-21) and experimentally attenuated (Tp-21-237) strains the immunocompetent cells of mouse spleens responded by active reactions.