Publications by authors named "E de Zwart"
Summary: Extensive human health data from cohort studies, national registries, and biobanks can reveal lifecourse risk factors impacting health. Combining these sources offers increased statistical power, rare outcome detection, replication of findings, and extended study periods. Traditionally, this required data transfer to a central location or separate partner analyses with pooled summary statistics, posing ethical, legal, and time constraints.
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- There is a rising rate of fatty liver disease in the western world, primarily due to steatosis, which can be caused by certain foods, excessive alcohol or fat intake, and some medications.
- Advances in understanding how chemicals cause steatosis have led to the creation of adverse outcome pathways (AOPs), outlining how chemical exposure results in liver fat buildup.
- In a study using zebrafish embryos, three pesticides were tested for their impact on liver triglyceride accumulation, showing that zebrafish are effective for evaluating these effects and confirming chemical-induced steatosis, with findings supporting that similar and different acting chemicals can add up in their effects.
Background: The introduction of the 1 mm cut-off for resection margin according to the Leeds Pathology Protocol has transformed the concept of surgical radicality. Its impact on nodal-positive resected pancreatic ductal adenocarcinoma patients is unclear. The aim of this study was to analyse the effect of margin clearance on survival among resected, nodal-positive pancreatic ductal adenocarcinoma patients whose specimens were analysed according to the Leeds Pathology Protocol.
View Article and Find Full Text PDFPancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis with a 5-year survival of less than 10%. More knowledge of the immune response developed in patients with PDAC is pivotal to develop better combination immune therapies to improve clinical outcome. In this study, we used mass cytometry time-of-flight to undertake an in-depth characterization of PBMCs from patients with PDAC and examine the differences with healthy controls and patients with benign diseases of the biliary system or pancreas.
View Article and Find Full Text PDFBackground: Human exposure to pesticides is being associated with feminisation for which a decrease of the anogenital distance (AGD) is a sensitive endpoint. Dose addition for the cumulative risk assessment of pesticides in food is considered sufficiently conservative for combinations of compounds with both similar and dissimilar modes of action (MoA).
Objective: The present study was designed to test the dose addition hypothesis in a binary mixture of endocrine active compounds with a dissimilar mode of action for the endpoint feminisation.