Publications by authors named "E de Ranieri"
Monoclonal gammopathy of renal significance (MGRS) refers to a group of renal disorders caused by a monoclonal immunoglobulin (MIg), secreted by a non-malignant B-cell clone. Unlike overt multiple myeloma or B-cell proliferation, MGRS does not meet those diagnostic criteria. However, it is associated with significant morbidity, due to severe renal, and sometimes systemic, lesions induced by the MIg.
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- - Newborn screening (NBS) has significantly advanced public health, particularly with innovations like tandem mass spectrometry, and is expected to further evolve with genomic testing.
- - While NBS typically involves multiple low-cost confirmation tests, there's concern about the feasibility of repeating expensive genetic tests like whole-genome sequencing for follow-up.
- - The study explores how to transition NBS data into diagnostic-grade data using single-nucleotide variants (SNVs), aiming to enhance rapid diagnosis and reduce family stress when genetic issues are suspected in newborns.
Lung cancer (LC) is the leading cause of cancer-related deaths. Although low-dose computed tomography (LD-CT) reduces mortality, its clinical use is limited by cost, radiation, and false positives. Therefore, there is an urgent need for non-invasive and cost-effective biomarkers.
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- Detailed method descriptions help scientists repeat experiments and get similar results.
- The European Commission PRO-MaP report gives important tips for researchers in life sciences.
- These tips help improve research quality and make it easier to share and reuse data.
The aging process contributes significantly to the onset of chronic diseases, which are the primary causes of global mortality, morbidity, and healthcare costs. Numerous studies have shown that the removal of senescent cells from tissues extends lifespan and reduces the occurrence of age-related diseases. Consequently, there is growing momentum in the development of drugs targeting these cells.
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