Advancing scaling science in health and social care: a scoping review and appraisal of scaling frameworks.

Background: Scaling is typically discussed as a way to amplify or expand a health innovation. However, there is limited knowledge about the specific techniques that can enhance access to or improve the quality of innovations, aiming to increase their positive impacts for the public good. We sought to identify, compare, and contrast scaling frameworks to advance the science and practice of scaling.

Antitumoral action of carvedilol-a repositioning study of the drug incorporated into mesoporous silica MCM-41.

We have studied repositioning of carvedilol (an antihypertensive drug) incorporated into MCM-41 mesoporous silica. The repositioning proposes a reduction in the slow pace of discovery of new drugs, as well as toxicological safety and a significant reduction in high research costs, making it an attractive strategy for researchers and large pharmaceutical companies. We obtained MCM-41 bysynthesis and functionalized it by post-synthesis grafting with aminopropyltriethoxysilane (APTES) only or with folic acid (FA), which gave MCM-41-APTES and MCM-41-APTES-FA, respectively.

Impact of printing layer thickness on the flexural strength of nanocomposite 3D printed resins: An in vitro comparative study.

Background: This study evaluated the influence of various printing layer thicknesses with silicon dioxide nanoparticles (SiONPs) incorporated as a reinforcement material on the flexural strength of 3D-printed denture base resins.

Material And Methods: Asiga (DentaBASE, Asiga, Erfurt, Germany) and NextDent (Denture 3D+, NextDent B.V.

Engagement of people with lived experience in studies published in high-impact psychiatry journals: meta-research review.

Background: We evaluated studies published in high-impact psychiatry journals to assess (1) the proportion that reported in articles whether they engaged people with lived experience; (2) the proportion that likely engaged people with lived experience; and, if engagement occurred, (3) stages of research (planning, conduct, interpretation, dissemination); and (4) engagement level (consult, involve, partner).

Methods: We searched PubMed on December 14, 2022, for articles in psychiatry journals with impact factor ≥ 10 and reviewed articles in reverse chronological order until 141 were included, based on pre-study precision estimation. We contacted authors to obtain information on engagement.

Exploring gender disparity in medicine: perceptions of female physicians in Lebanon.

Background: Global research on gender bias has highlighted key trends in discrimination and inequality across various fields, including medicine. In Lebanon, a nation celebrated for its diverse cultural landscape and increasing female representation in medical education, there has been a notable absence of studies exploring gender dynamics in the medical profession.

Methods: To address this gap, we conducted a cross-sectional study using an online survey to explore the Lebanese population's perceptions towards female physicians and the quality of care they provide.