Publications by authors named "E Zarra"
Background: Advanced Hybrid Closed-Loop system (AHCL) has profoundly changed type 1 diabetes therapy. This study primarily aimed to assess the impact on Glycemia Risk Index (GRI) and other continuous glucose monitoring (CGM) metrics when switching from one of four insulin strategies to AHCL in type 1 adult patients.
Methods: A single-center, retrospective pre/post observational study; 198 patients (age 44.
In recent years, GLP-1 receptor agonists (GLP-1RA), and SGLT-2 inhibitors (SGLT-2i) have become available, which have become valuable additions to therapy for type 2 diabetes as they are associated with low risk for hypoglycemia and cardiovascular benefits. Indeed, SGLT-2i have emerged as a promising class of agents to treat heart failure (HF). By inhibiting SGLT-2, these agents lead to excretion of glucose in urine with subsequent lowering of plasma glucose, although it is becoming clear that the observed benefits in HF cannot be explained by glucose-lowering alone.
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- The study examines the impact of glycemic control on COVID-19 outcomes in diabetic patients, focusing on factors like hyperglycemia, inflammation, and clinical history.
- It involved a retrospective analysis of 291 diabetic patients, finding that high blood glucose levels at admission and poor kidney function significantly increased the risk of mortality and longer hospital stays.
- Interestingly, while hyperglycemia directly correlated with higher mortality, certain inflammatory markers showed indirect effects, and a higher basophil count appeared to be protective against mortality.
Aim: To clarify whether the vasoconstrictory response is impaired and to study vascular function in patients with migraine during the headache attack.
Methods: We studied vascular reactivity in the resistance arteries by using the forearm perfusion technique associated with plethysmography. We measured forearm blood flow by strain-gauge plethysmography during intra-brachial infusion of acetylcholine, sodium nitroprusside or norepinephrine in 11 controls and 13 patients with migraine, 11 of them (M) in the interval between the migraine attacks and 4 during a headache attack (MH).
Objective: A retrospective study to evaluate the changes in TSH concentrations in diabetic patients treated or not treated with metformin and/or L-thyroxine (L-T(4)).
Methods: Three hundred and ninety three euthyroid diabetic patients were divided into three groups on the basis of metformin and/or L-T(4) treatment: Group (M-/L-), 119 subjects never treated with metformin and L-T(4); Group (M+/L-), 203 subjects who started metformin treatment at recruitment; and Group (M+/L+), 71 patients on L-T(4) who started metformin recruitment.
Results: The effect of metformin on serum TSH concentrations was analyzed in relation to the basal value of TSH (below 2.