The Experience of Stigma in People Affected by Fibromyalgia: A Metasynthesis.

Aim: To review the qualitative literature regarding how people with fibromyalgia experience and are impacted by stigma.

Design: A systematic review and metasynthesis of qualitative studies was conducted following the Thomas and Harden method.

Methods: The electronic databases PubMed, CINAHL, PsycInfo, Embase and Scopus were queried (September 2023).

In situ staining with antibodies cross-reactive in pigs, cattle, and white-tailed deer facilitates understanding of biological tissue status and immunopathology.

Identifying cellular markers within archived formalin-fixed, paraffin-embedded (FFPE) tissues is critical for understanding tissue landscapes impacting animal health, but in situ detection methods are limited in veterinary species by a restricted toolbox of species-compatible immunoreagents. We identify antibodies with conserved in situ reactivity to IBA-1 (macrophages/dendritic cells), CD3ε (T cells), Pax5 (B cells), Ki-67 (cycling cells), and cytokeratin type I/II (epithelial cells) in FFPE tissues of pigs, cattle, and white-tailed deer. Multiplexed brightfield detection (IBA-1/CD3ε/Pax5) in lymph nodes of all three species demonstrated species-specific and species-conserved features of cellular architecture.

The Sire Effect on Gestational Length in Wagyu Cattle.

This study investigated the factors influencing gestation length in a herd of Wagyu cattle in Rio Grande do Sul, Brazil. Fifty-five multiparous purebred Wagyu cows underwent a Fixed-Time Artificial Insemination (FTAI) protocol using semen from a bull randomly selected from five bulls representing three distinct genetic lines. Following birth, we recorded the calves' gender, weight, and gestation length.

XENTURION is a population-level multidimensional resource of xenografts and tumoroids from metastatic colorectal cancer patients.

The breadth and depth at which cancer models are interrogated contribute to the successful clinical translation of drug discovery efforts. In colorectal cancer (CRC), model availability is limited by a dearth of large-scale collections of patient-derived xenografts (PDXs) and paired tumoroids from metastatic disease, where experimental therapies are typically tested. Here we introduce XENTURION, an open-science resource offering a platform of 128 PDX models from patients with metastatic CRC, along with matched PDX-derived tumoroids.