Publications by authors named "E Zamparini"
: The main aim of this study was to describe the epidemiology of infected non-unions (INUs) managed at an Infectious Disease (ID) referral centre and to investigate the factors associated with treatment failure. : This was an observational retrospective study on adult patients with INUs managed between 2012 and 2018 at the ID Unit of the IRCCS Azienda Ospedaliero-Universitaria di Bologna, an Italian ID referral centre for bone and joint infections. Patients were observed for at least 24 months.
View Article and Find Full Text PDFBackground And Objective: Dalbavancin is increasingly used for the long-term treatment of chronic osteoarticular infections. A population pharmacokinetic/pharmacodynamic (PK/PD) analysis for assessing the relationship between dalbavancin exposure and C-reactive protein (C-RP) over time was conducted.
Methods: Non-linear mixed-effect modeling was fitted to dalbavancin and C-RP concentrations.
Background: Pyroglutamic acidosis is a rare cause of high anion gap metabolic acidosis. Most cases of paracetamol related pyroglutamic acidosis are described in malnourished women and patients with kidney/liver failure, alcohol use or severe sepsis. In this report, we describe how pyroglutamic acidosis could be related to the use of chronic therapeutic paracetamol with only malnutrition as an associated risk factor.
View Article and Find Full Text PDFDalbavancin is increasingly being used for long-term treatment of subacute and chronic staphylococcal infections. In this study, a new Bayesian model was implemented and validated using MwPharm software for accurately forecasting the duration of pharmacodynamic target attainment above the efficacy thresholds of 4.02 mg/L or 8.
View Article and Find Full Text PDFArticle Synopsis
- Periprosthetic joint infections (PJI) and fracture-related infections (FRI) of the distal femur can lead to significant bone loss, and a two-stage treatment protocol utilizing articulated silver-coated megaprosthesis was studied.
- A review of three institutions included 45 patients, showing an estimated 91.1% survival rate free from recurrence of infection two years after surgery, with complications primarily involving non-infection-related issues.
- Significant findings indicated that a longer resection length negatively impacted infection control, while the initial diagnosis (PJI or FRI) did not significantly affect outcomes, affirming the safety and effectiveness of this treatment approach.