[Retrospective analysis of adverse cutaneous drug reactions in patients hospitalized in Department of Dermatology and Venereology of Pomeranian Medical University in 1996-2006].

Introduction: Every adverse and undesirable event observed after administration of the therapeutic dose of the drug is defined as adverse drug reaction. The aim of the study was to evaluate the incidence frequency of cutaneous adverse drug reactions, to define the drugs inducing such reactions and to define the type of the most frequently found lesions in patients admitted to Department of Dermatology and Venereology of Pomeranian Medical University in Szczecin (PAM) in 1996-2006.

Material And Methods: A retrospective analysis of medical files of the patients, who were hospitalized in the Department of Dermatology and Venereology of PAM in Szczecin in 1996-2006, was carried out.

Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march.

Background: Childhood eczema often precedes the development of asthma and allergic rhinitis in the so-called atopic march. Recently, 2 loss-of-function mutations in the gene encoding the epidermal barrier protein filaggrin were reported to be predisposing factors for eczema and concomitant asthma, suggesting a possible role in disease transition.

Objective: We aimed to assess the importance of filaggrin loss-of-function mutations in the susceptibility to eczema and associated clinical phenotypes.

[Physiological skin changes during pregnancy].

Associated with pregnancy skin changes appear at approximately 90% pregnant. For the necessity of proper and complex care of the pregnant woman. The actualization of this knowledge among the family doctors and the obstetricians is crucial.

[Protection of the skin from harmful ultraviolet radiation].

Ultraviolet radiation from the sun or artificial sources can exert beneficial and/or damaging effect on human skin. Excessive UV radiation has been implicated in the increased incidence of skin malignancies and accelerated skin photoaging. Thus, the skin requires adequate protection and sunscreens are useful for this purpose.

CDKN2A common variants and their association with melanoma risk: a population-based study.

The population frequencies of the CDKN2A variants remain undetermined. In Poland there are three common variants of CDKN2A: an alanine to threonine substitution (A148T), Nt500c>g and Nt540c>t, which have been detected in other populations. To establish if they are associated with an increased malignant melanoma (MM) risk we did an association study based on genotyping 471 patients with MM and 1,210 random control subjects from the same Polish population.