Publications by authors named "E Zakharchuk"

Currently, much is known about the causative agent of Covid-19. The situation with the spread of a new coronavirus infection is under control. Preventive measures against this disease have been developed and are being actively implemented.

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Article Synopsis
  • Diffuse toxic goiter (DTG) is an autoimmune disorder where the body produces antibodies against TSH receptors, often occurring alongside other autoimmune conditions.
  • A case study of a 15-year-old patient showed DTG with one-sided ophthalmopathy and functional decline in the musculoskeletal system, emphasizing the impact on dental health as well.
  • The report highlights the potential for disease relapse even after treatment, suggesting the need for careful monitoring and possible surgical options, and underscores the importance of early diagnosis by healthcare professionals.
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The article explains the biochemical aspects of interaction of natural polyphenol resveratrol and immune system. The molecular mechanisms of action of resveratrol are given. The anti-inflammatory effect of resveratrol is described in detail.

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The article represents the data characterizing the use of resveratrol in the treatment of various diseases, including endocrinological and neurological. It was shown that resveratrol is widely used in the treatment of various diseases due to its ability to actively suppress the inflammatory process. At the same time, in autoimmune diseases resveratrol inhibits the function of the entire population of T-cells, but when it comes to the neoplastic process, it only inhibits the activity of a subpopulation of T-cells (Treg).

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The article reflects the main links of pathogenesis and diagnostic criteria for autoimmune thyroiditis (AIT) and subclinical hypothyroidism as well as presents formulated features of signs and symptoms, diagnosis, and therapy of this disease in children. Here, we present a case report of an adolescent patient with AIT that was treated with L-thyroxine. The feature of this case was the development of laboratory-confirmed drug-induced hyperthyroidism against the background of hypersensitivity to the drug, what required correction of the therapy.

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