New Frontiers in Diagnosis and Therapy of Circulating Tumor Markers in Cerebrospinal Fluid In Vitro and In Vivo.

One of the greatest challenges in neuro-oncology is diagnosis and therapy (theranostics) of leptomeningeal metastasis (LM), brain metastasis (BM) and brain tumors (BT), which are associated with poor prognosis in patients. Retrospective analyses suggest that cerebrospinal fluid (CSF) is one of the promising diagnostic targets because CSF passes through central nervous system, harvests tumor-related markers from brain tissue and, then, delivers them into peripheral parts of the human body where CSF can be sampled using minimally invasive and routine clinical procedure. However, limited sensitivity of the established clinical diagnostic cytology in vitro and MRI in vivo together with minimal therapeutic options do not provide patient care at early, potentially treatable, stages of LM, BM and BT.

[COMPREHENSIVE PROPHYLAXIS OF EARLY THROMBOEMBOLISM AND HEMORRHAGE AFTER LARGE JOINT ENDOPROSTHETIC SURGERY].

We examined 160 patients treated by endoprosthetic surgery of hip, knee, shoulder and elbow joints. 80 patients received i/v injections of 250 mg tranexam 30 min before and 4 hr after surgery. 220 mg ofpradax was given within 10-12 hr after surgery and thereafter on a daily basis.

[Optimization of aspiration-irrigation drainage of purulent wounds].

The aim of the investigation was to improve the methods of sanitation of purulent foci. Efficacy of the purulent cavity lavage increased due to the changed direction of the flow of antiseptic solution. Experimental investigations showed that the down-flow lavage of purulent wounds with antiseptics was not enough.

[Active closed method of surgical treatment in postinjection purulent complications].

The work analyses the results of treatment of 450 patients with postinjection purulent complications of the soft tissues which accounted for 11.9% of the total structure of purulent diseases. The generally accepted methods were applied in the treatment of 280 patients.